Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0458 | 0.0458 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.2119 | 1 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0259 | 1 | 1 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0259 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.2119 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1044 | 0.1044 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1044 | 0.0872 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.2119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1044 | 0.1044 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0619 | 0.0969 |
Plasmodium vivax | choline kinase, putative | 0.0259 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0619 | 0.0969 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.2119 | 0.2119 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1044 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0188 | 0.0188 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.2119 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0619 | 1 |
Plasmodium falciparum | choline kinase | 0.0259 | 1 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.2119 | 0.1969 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0259 | 1 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.0458 | 0.0275 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0458 | 0.7399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.