Detailed information for compound 132733

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.541 | Formula: C21H22N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCN(C(=O)c1c(O)c2cc(SC)ccc2n(c1=O)C)c1ccccc1
  • InChi: 1S/C21H22N2O3S2/c1-22-17-10-9-15(28-3)13-16(17)19(24)18(20(22)25)21(26)23(11-12-27-2)14-7-5-4-6-8-14/h4-10,13,24H,11-12H2,1-3H3
  • InChiKey: XUQNKLNDKSWEBW-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.7298 0.7298
Echinococcus multilocularis SH2 motif 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0064 1 1
Brugia malayi Raf kinase 0.0014 0.0375 0.0375
Echinococcus granulosus protein tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.7298 0.7298
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.0064 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.7298 0.7298
Echinococcus granulosus c src tyrosine kinase 0.0064 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0014 0.0375 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase ABL1 0.0064 1 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0014 0.0375 0.0375
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0375 0.0375
Schistosoma mansoni serine/threonine RGC 0.0014 0.0375 0.0375
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.005 0.7298 0.7298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/ABL protein kinase 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis c src tyrosine kinase 0.0064 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Schistosoma mansoni adapter molecule crk 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Echinococcus multilocularis tensin 0.005 0.7298 0.7298
Brugia malayi hypothetical protein 0.0014 0.0375 0.0375
Plasmodium falciparum protein kinase, putative 0.0014 0.0375 0.5
Giardia lamblia Protein 21.1 0.0014 0.0375 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0014 0.0375 0.0375
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0375 0.0375
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.5706 0.5706
Brugia malayi Protein-tyrosine phosphatase containing protein 0.005 0.7298 0.7298
Schistosoma mansoni tensin-related 0.005 0.7298 0.7298
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 1 1
Plasmodium falciparum protein kinase, putative 0.0014 0.0375 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.7298 0.7298
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0014 0.0375 0.0375
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0375 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus protein kinase 0.0014 0.0375 0.0375
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tensin 0.005 0.7298 0.7298
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0014 0.0375 0.5
Onchocerca volvulus 0.005 0.7298 0.7192
Echinococcus granulosus SH2 domain containing adapter protein F 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/ALK protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0375 0.0375
Brugia malayi RhoGAP domain containing protein 0.005 0.7298 0.7298
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0375 0.0375
Echinococcus multilocularis suppressor of cytokine signaling 6 0.005 0.7298 0.7298
Echinococcus granulosus N chimaerin 0.005 0.7298 0.7298
Brugia malayi Variant SH3 domain containing protein 0.005 0.7298 0.7298
Echinococcus granulosus natriuretic peptide receptor 1 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0064 1 1
Brugia malayi Sex muscle abnormal protein 5 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.005 0.7298 0.7298
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0064 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Toxoplasma gondii STE kinase 0.0014 0.0375 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.005 0.7298 0.7298
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.7298 0.7298
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.7298 0.7298
Trypanosoma cruzi protein kinase, putative 0.0014 0.0375 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0064 1 1
Echinococcus granulosus tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0014 0.0375 0.0375
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Plasmodium vivax protein kinase, putative 0.0014 0.0375 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus kinase suppressor of Ras 1 0.0014 0.0375 0.0375
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0014 0.0375 0.0375
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.005 0.7298 0.7192
Echinococcus granulosus integrin linked protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase pr2 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Brugia malayi Furin-like cysteine rich region family protein 0.0014 0.0375 0.0375
Brugia malayi SRC-1 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Plasmodium falciparum protein kinase, putative 0.0014 0.0375 0.5
Echinococcus multilocularis protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0375 0.0375
Echinococcus multilocularis SH2 motif 0.005 0.7298 0.7298
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Src64B 0.0064 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) variant SH3 domain-containing protein 0.005 0.7298 0.7298
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Trypanosoma brucei protein kinase, putative 0.0014 0.0375 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0375 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) sex muscle abnormal protein 5 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0064 1 1
Echinococcus multilocularis tyrosine kinase 0.0064 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/RYK protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus SH2 motif 0.005 0.7298 0.7298
Onchocerca volvulus 0.0064 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.5178 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.7298 0.7298
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.6444 0.6444
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0064 1 1
Brugia malayi Tensin 0.005 0.7298 0.7298
Echinococcus granulosus insulin receptor 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Echinococcus multilocularis 0.005 0.7298 0.7298
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0375 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus suppressor of cytokine signaling 6 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/ACK protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Blk 0.0064 1 1
Brugia malayi Variant SH3 domain containing protein 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0375 0.0375
Echinococcus granulosus SHC transforming protein 3 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0064 1 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.005 0.7298 0.7192
Echinococcus multilocularis signal transduction protein lnk realted 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.005 0.7298 0.7298
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus growth factor receptor bound protein 2 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FAK protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Src42A 0.0064 1 1
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Echinococcus multilocularis SHC transforming protein 3 0.005 0.7298 0.7298
Echinococcus granulosus tensin C1 domain containing phosphatase 0.005 0.7298 0.7298
Schistosoma mansoni growth factor receptor-bound protein 0.005 0.7298 0.7298
Loa Loa (eye worm) STAT protein 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase Lyn 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0064 1 1
Brugia malayi integrin-linked kinase 0.0014 0.0375 0.0375
Schistosoma mansoni SH2A 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Echinococcus multilocularis integrin linked protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0014 0.0375 0.0375
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.6444 0.6444
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0375 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine kinase 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0375 0.0375
Brugia malayi Variant SH3 domain containing protein 0.005 0.7298 0.7298
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.005 0.7298 0.7298
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0375 0.5
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0064 1 1
Onchocerca volvulus 0.005 0.7298 0.7192
Entamoeba histolytica SH2-protein kinase domain containing protein 0.005 0.7298 0.7192
Trypanosoma brucei Pseudokinase, putative 0.0014 0.0375 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0014 0.0375 0.0375
Brugia malayi hypothetical protein 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Brugia malayi C-terminal src kinase protein 1 0.0014 0.0375 0.0375
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus multilocularis SH2 domain containing adapter protein F 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus fibroblast growth factor receptor 4 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Giardia lamblia Kinase 0.0014 0.0375 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus expressed conserved protein 0.005 0.7298 0.7298
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.7298 0.7298
Echinococcus multilocularis N chimaerin 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 1 1
Schistosoma mansoni protein tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus SH2 motif 0.005 0.7298 0.7298
Schistosoma mansoni ephrin receptor 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0064 1 1
Onchocerca volvulus 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Entamoeba histolytica protein kinase, putative 0.005 0.7298 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis SH2 domain containing protein 7 0.005 0.7298 0.7298
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis activated cdc42 kinase 1 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0014 0.0375 0.0375
Onchocerca volvulus 0.0064 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0014 0.0375 0.0375
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0064 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0014 0.0375 0.0375
Giardia lamblia Kinase, NEK 0.0014 0.0375 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0014 0.0375 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.005 0.7298 0.7298
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus NCK adaptor protein 0.005 0.7298 0.7298
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Brugia malayi ephrin receptor 1 precursor 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase shark 0.0064 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.005 0.7298 0.7298
Schistosoma mansoni tensin 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis growth factor receptor bound protein 2 0.005 0.7298 0.7298
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis raf serine:threonine protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis natriuretic peptide receptor 1 0.0014 0.0375 0.0375
Echinococcus multilocularis heat shock protein 70 0.0014 0.0375 0.0375
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.7298 0.7298
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0375 0.5
Echinococcus multilocularis SH2 motif 0.005 0.7298 0.7298
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0014 0.0375 0.5
Onchocerca volvulus 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0375 0.0375
Schistosoma mansoni nck2/grb4 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.005 0.7298 0.7298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0064 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.7298 0.7298
Leishmania major protein kinase, putative 0.0014 0.0375 0.5
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis FL cytokine receptor 0.0014 0.0375 0.0375
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Brugia malayi tRNA modification GTPase TrmE family protein 0.005 0.7298 0.7298
Loa Loa (eye worm) variant SH3 domain-containing protein 0.005 0.7298 0.7298
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Onchocerca volvulus 0.005 0.7298 0.7192
Onchocerca volvulus 0.005 0.7298 0.7192
Brugia malayi cytokine inducible SH2-containing protein 5 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0064 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0064 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.5706 0.5706
Loa Loa (eye worm) TK/DDR protein kinase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0375 0.5
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase HCK 0.0014 0.0375 0.0375
Echinococcus granulosus suppressor of cytokine signaling 7 0.005 0.7298 0.7298
Onchocerca volvulus 0.005 0.7298 0.7192
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Toxoplasma gondii protein kinase 0.0014 0.0375 0.5
Onchocerca volvulus 0.0064 1 1
Schistosoma mansoni GTPase activating protein 0.005 0.7298 0.7298
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.5706 0.5706
Loa Loa (eye worm) TK/CSK protein kinase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0064 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis transfer RNA-Thr 0.0014 0.0375 0.0375
Schistosoma mansoni protein kinase 0.0014 0.0375 0.0375
Trypanosoma cruzi protein kinase, putative 0.0014 0.0375 0.5
Brugia malayi protein-tyrosine kinase 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0064 1 1
Schistosoma mansoni shc transforming protein 0.005 0.7298 0.7298
Brugia malayi Tyrosine-protein kinase PR2 0.0014 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus hypothetical protein 0.005 0.7298 0.7298
Plasmodium falciparum tyrosine kinase-like protein 0.0014 0.0375 0.5
Schistosoma mansoni tensin 0.005 0.7298 0.7298
Echinococcus granulosus tyrosine protein kinase pr2 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0064 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0064 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.005 0.7298 0.7298
Echinococcus granulosus ephrin type A receptor 4 A 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Brugia malayi bone morphogenetic protein type 1 receptor 0.0014 0.0375 0.0375
Brugia malayi Variant SH3 domain containing protein 0.005 0.7298 0.7298
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0375 0.0375
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.5706 0.5706
Entamoeba histolytica SH2 domain containing protein 0.005 0.7298 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Echinococcus multilocularis tensin 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Onchocerca volvulus 0.0064 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.005 0.7298 0.7298
Loa Loa (eye worm) RhoGAP domain-containing protein 0.005 0.7298 0.7298
Brugia malayi hypothetical protein 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine kinase 0.0064 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus multilocularis activin receptor type 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Srms 0.0064 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0375 0.0375
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0064 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0014 0.0375 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0014 0.0375 0.0375
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0014 0.0375 0.0375
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.5178 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0014 0.0375 0.0375
Echinococcus granulosus activin receptor type 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus tensin 0.005 0.7298 0.7298
Giardia lamblia Kinase, NEK 0.0014 0.0375 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0014 0.0375 0.0375
Onchocerca volvulus 0.005 0.7298 0.7192
Echinococcus multilocularis tyrosine protein kinase shark 0.0064 1 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0014 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase csk 0.0014 0.0375 0.0375
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0014 0.0375 0.0375
Schistosoma mansoni vav2 0.005 0.7298 0.7298
Echinococcus multilocularis protein tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.7298 0.7298
Brugia malayi Protein kinase domain containing protein 0.0064 1 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0014 0.0375 0.0375
Echinococcus multilocularis insulin receptor 0.0014 0.0375 0.0375
Echinococcus multilocularis protein KINase family member (kin 25) 0.0014 0.0375 0.0375
Schistosoma mansoni ephrin receptor 0.0014 0.0375 0.0375
Schistosoma mansoni tensin-related 0.005 0.7298 0.7298
Loa Loa (eye worm) SRC-1 0.0064 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0014 0.0375 0.0375
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0014 0.0375 0.0375
Brugia malayi SH2 domain containing protein 0.0064 1 1
Loa Loa (eye worm) TK protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis protein kinase 0.0014 0.0375 0.0375
Brugia malayi Protein kinase domain containing protein 0.0014 0.0375 0.0375
Echinococcus granulosus activated cdc42 kinase 1 0.0014 0.0375 0.0375
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine-protein kinase zap-70 0.005 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0014 0.0375 0.0375
Brugia malayi Tyrosine-protein kinase abl-1 0.0064 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0375 0.5
Leishmania major protein kinase, putative 0.0014 0.0375 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis NCK adaptor protein 0.005 0.7298 0.7298
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0014 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0014 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.0064 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0014 0.0375 0.0375
Leishmania major hypothetical protein, conserved 0.0014 0.0375 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.4645 0.4645
Echinococcus multilocularis tyrosine protein kinase HCK 0.0014 0.0375 0.0375
Brugia malayi hypothetical protein 0.0014 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.005 0.7298 0.7298
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0064 1 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0375 0.0375
Echinococcus granulosus SH2 domain containing protein 7 0.005 0.7298 0.7298

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 65 % Antinephritic activity of the compound against Graft-Versus-Host Disease (GVHD) induced (C57BL/6DBA/2)F1 mice at a dose of 32 mg/kg administered perorally ChEMBL. 12161149
Inhibition (functional) = 65 % Antinephritic activity of the compound against Graft-Versus-Host Disease (GVHD) induced (C57BL/6DBA/2)F1 mice at a dose of 32 mg/kg administered perorally ChEMBL. 12161149

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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