Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.8 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 26.9 % |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | kinesin-5 | 0.0147 | 0.1204 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0079 | 0.0595 | 0.2813 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1716 | 0.1975 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0079 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.025 | 0.2117 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0171 | 0.1413 | 0.6673 |
Echinococcus granulosus | GPCR family 2 | 0.0079 | 0.0595 | 0.0595 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1413 | 0.6673 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.025 | 0.2117 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0147 | 0.1204 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0079 | 0.0595 | 0.2813 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.1429 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0595 | 0.0686 |
Schistosoma mansoni | kinesin eg-5 | 0.0147 | 0.1204 | 0.1386 |
Plasmodium vivax | kinesin-5 | 0.0147 | 0.1204 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0986 | 0.8687 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.2117 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0079 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0147 | 0.1204 | 0.5689 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0595 | 0.0686 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.3039 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.025 | 0.2117 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.3039 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.1429 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0595 | 0.0686 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0595 | 0.0686 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.0946 | 0.4468 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.0946 | 0.4468 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0079 | 0.0595 | 0.0595 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0079 | 0.0595 | 0.2813 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3039 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.0946 | 0.4468 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.1429 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1413 | 0.1626 |
Echinococcus multilocularis | GPCR, family 2 | 0.0079 | 0.0595 | 0.0595 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0079 | 0.0595 | 0.0595 |
Echinococcus granulosus | geminin | 0.0205 | 0.1716 | 0.1716 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1716 | 0.1975 |
Brugia malayi | Kinesin motor domain containing protein | 0.0147 | 0.1204 | 0.5689 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0595 | 0.2813 |
Echinococcus multilocularis | kinesin family 1 | 0.1134 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.