Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0298 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0298 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1796 | 0.2067 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0298 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0141 | 0.1207 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0298 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0298 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0212 | 0.1756 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0294 | 0.0338 |
Echinococcus multilocularis | kinesin family 1 | 0.1087 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0.0298 | 0.5 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0298 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0298 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0298 | 0.2469 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2476 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0294 | 0.0338 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0298 | 0.0343 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0298 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Schistosoma mansoni | hypothetical protein | 0.0946 | 0.8687 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.026 | 0.026 |
Entamoeba histolytica | kinesin, putative | 0.0141 | 0.1207 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1796 | 0.2067 |
Echinococcus granulosus | geminin | 0.0205 | 0.1796 | 0.1796 |
Giardia lamblia | Kinesin-5 | 0.0141 | 0.1207 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0141 | 0.1207 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0298 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0141 | 0.1207 | 1 |
Onchocerca volvulus | 0.0043 | 0.0298 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0298 | 0.0343 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.026 | 0.026 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0298 | 0.2469 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0298 | 0.0298 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0298 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1796 | 0.1796 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0298 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0298 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0141 | 0.1207 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0298 | 1 |
Onchocerca volvulus | 0.0043 | 0.0298 | 0.5 | |
Plasmodium vivax | kinesin-5 | 0.0141 | 0.1207 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0298 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.026 | 0.2157 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0298 | 0.2469 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0298 | 0.2469 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0298 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0298 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0298 | 0.2469 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0298 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0141 | 0.1207 | 0.1389 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0298 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.026 | 0.2157 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.