Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | meiotic recombination protein DMC1, putative | 0.011 | 0.7222 | 1 |
Wolbachia endosymbiont of Brugia malayi | transcription elongation factor NusA | 0.0075 | 0.3839 | 0.5 |
Trypanosoma cruzi | meiotic recombination protein DMC1, putative | 0.011 | 0.7222 | 1 |
Loa Loa (eye worm) | meiotic recombination protein DMC1/LIM15 | 0.0035 | 0.0084 | 0.0084 |
Giardia lamblia | hypothetical protein | 0.0075 | 0.3839 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0039 | 0.0428 | 0.0592 |
Schistosoma mansoni | DNA repair protein RAD51 | 0.011 | 0.7222 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0039 | 0.0428 | 0.0916 |
Brugia malayi | intracellular kinase | 0.0039 | 0.0428 | 0.0428 |
Chlamydia trachomatis | Holliday junction ATP-dependent DNA helicase RuvA | 0.0075 | 0.3839 | 0.5 |
Mycobacterium leprae | Probable Holliday junction DNA helicase component RuvA | 0.0075 | 0.3839 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0039 | 0.0428 | 0.0482 |
Brugia malayi | Meiotic recombination protein DMC1/LIM15 homolog, putative | 0.0035 | 0.0084 | 0.0084 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0075 | 0.3839 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0039 | 0.0428 | 0.0428 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0039 | 0.0428 | 0.0482 |
Chlamydia trachomatis | excinuclease ABC subunit C | 0.0075 | 0.3839 | 0.5 |
Loa Loa (eye worm) | rad51 | 0.011 | 0.7222 | 0.7222 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0039 | 0.0428 | 0.0592 |
Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0428 | 0.0482 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0039 | 0.0428 | 0.0592 |
Giardia lamblia | DNA helicase | 0.0075 | 0.3839 | 1 |
Echinococcus granulosus | DNA excision repair protein ERCC 1 | 0.0075 | 0.3839 | 0.5316 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0039 | 0.0428 | 0.0482 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0039 | 0.0428 | 0.0482 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0039 | 0.0428 | 0.0482 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0039 | 0.0428 | 1 |
Leishmania major | RAD51/dmc1 protein | 0.011 | 0.7222 | 1 |
Trypanosoma cruzi | DNA repair protein RAD51, putative | 0.011 | 0.7222 | 1 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.0075 | 0.3839 | 0.5316 |
Mycobacterium ulcerans | excinuclease ABC subunit C | 0.0075 | 0.3839 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0039 | 0.0428 | 1 |
Echinococcus granulosus | dna repair protein rad51 1 | 0.011 | 0.7222 | 1 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0075 | 0.3839 | 0.5261 |
Onchocerca volvulus | 0.0039 | 0.0428 | 0.0428 | |
Entamoeba histolytica | DNA repair protein RAD51, putative | 0.011 | 0.7222 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0039 | 0.0428 | 0.0916 |
Mycobacterium tuberculosis | Probable holliday junction DNA helicase RuvA | 0.0075 | 0.3839 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0039 | 0.0428 | 1 |
Trypanosoma cruzi | DNA repair protein RAD51, putative | 0.011 | 0.7222 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0039 | 0.0428 | 0.0482 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0139 | 1 | 1 |
Treponema pallidum | Holliday junction DNA helicase (ruvA) | 0.0075 | 0.3839 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Holliday junction DNA helicase RuvA | 0.0075 | 0.3839 | 0.5 |
Brugia malayi | DNA repair protein RAD51 homolog 1 | 0.011 | 0.7222 | 0.7222 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0039 | 0.0428 | 0.0592 |
Echinococcus multilocularis | dna repair protein rad51 1 | 0.011 | 0.7222 | 1 |
Toxoplasma gondii | meiotic recombination protein DMC1 family protein | 0.011 | 0.7222 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0039 | 0.0428 | 0.0592 |
Onchocerca volvulus | Meiotic recombination protein DMC1\/LIM15 homolog | 0.0035 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0039 | 0.0428 | 0.0428 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.0075 | 0.3839 | 0.5316 |
Mycobacterium ulcerans | Holliday junction DNA helicase RuvA | 0.0075 | 0.3839 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Trichomonas vaginalis | meiosis-specific recA homolog Dmc1 | 0.011 | 0.7222 | 1 |
Chlamydia trachomatis | DNA ligase | 0.0075 | 0.3839 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | > 35 uM | PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] | ChEMBL. | No reference |
AC50 (functional) | > 35 uM | PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.