Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.487 | 0.8679 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.5607 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0738 | 0.128 | 0.1475 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.5607 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0738 | 0.128 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0738 | 0.128 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0738 | 0.128 | 0.128 |
Echinococcus multilocularis | 0.0738 | 0.128 | 0.128 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.008 | 0.0103 | 0.0119 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0738 | 0.128 | 0.1475 |
Plasmodium vivax | hypothetical protein, conserved | 0.0738 | 0.128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0282 | 0.2205 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0738 | 0.128 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0738 | 0.128 | 0.128 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0282 | 0.2205 |
Onchocerca volvulus | 0.0738 | 0.128 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.487 | 0.8679 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0738 | 0.128 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0282 | 0.0282 |
Mycobacterium ulcerans | oxidoreductase | 0.0738 | 0.128 | 0.128 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0282 | 0.0282 |
Schistosoma mansoni | amine oxidase | 0.0738 | 0.128 | 0.128 |
Brugia malayi | hypothetical protein | 0.0738 | 0.128 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.5607 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0738 | 0.128 | 0.128 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0738 | 0.128 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0738 | 0.128 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0738 | 0.128 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.5607 | 1 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0738 | 0.128 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.008 | 0.0103 | 0.0103 |
Brugia malayi | SWIRM domain containing protein | 0.0738 | 0.128 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0738 | 0.128 | 0.128 |
Mycobacterium ulcerans | monoamine oxidase | 0.0738 | 0.128 | 0.128 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0738 | 0.128 | 0.128 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0738 | 0.128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0282 | 0.0325 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0738 | 0.128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0738 | 0.128 | 0.1475 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0738 | 0.128 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0073 | 0.009 | 0.009 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0738 | 0.128 | 0.128 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0738 | 0.128 | 0.1475 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0282 | 0.2205 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.128 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0738 | 0.128 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8437 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 3.9811 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.