Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0941 | 0.9587 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0941 | 0.9587 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0941 | 0.9587 | 1 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0941 | 0.9587 | 1 |
Leishmania major | silent information regulator 2, putative | 0.0941 | 0.9587 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0941 | 0.9587 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0941 | 0.9587 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0941 | 0.9587 | 0.9508 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.4467 | 0.359 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0199 | 0.1599 | 0.5 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0199 | 0.1599 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0941 | 0.9587 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0941 | 0.9587 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0664 | 0.6607 | 0.627 |
Plasmodium vivax | hypothetical protein, conserved | 0.0199 | 0.1599 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0664 | 0.6607 | 0.627 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0199 | 0.1599 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0199 | 0.1599 | 0.1668 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0941 | 0.9587 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0199 | 0.1599 | 0.1668 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0941 | 0.9587 | 1 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0199 | 0.1599 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.6607 | 0.627 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0664 | 0.6607 | 0.6892 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0664 | 0.6607 | 0.627 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0664 | 0.6607 | 0.5962 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0664 | 0.6607 | 0.627 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0199 | 0.1599 | 0.1668 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0199 | 0.1599 | 0.5 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0664 | 0.6607 | 0.627 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0941 | 0.9587 | 0.9508 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0941 | 0.9587 | 1 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0941 | 0.9587 | 1 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0199 | 0.1599 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0664 | 0.6607 | 0.627 |
Giardia lamblia | Hypothetical protein | 0.0941 | 0.9587 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0941 | 0.9587 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0664 | 0.6607 | 0.627 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0199 | 0.1599 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0941 | 0.9587 | 1 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0199 | 0.1599 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.