Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.6522 | 0.6433 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.6522 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0248 | 0.0000000054104 |
Leishmania major | hypothetical protein, conserved | 0.003 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0024 | 0.6522 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.397 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1025 | 0.1239 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.397 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.6522 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.6522 | 0.6433 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0024 | 0.6522 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.6522 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 0.6522 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.6522 | 0.6522 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.6522 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.6522 | 0.6433 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.6522 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0248 | 0.0248 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.6522 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0248 | 0.0248 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.6522 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0024 | 0.6522 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0024 | 0.6522 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0248 | 0.0381 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 0.6522 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0248 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 0.6522 | 0.6433 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 0.6522 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.6522 | 0.397 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0621 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.