Detailed view for Tbg972.8.6870

Basic information

TDR Targets ID: 544022
Trypanosoma brucei gambiense, ATP-dependent DEAD/H DNA helicase recQ, putative
Source Database / ID: 

pI: 7.5657 | Length (AA): 1548 | MW (Da): 167796 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00270   DEAD/DEAH box helicase
PF00271   Helicase conserved C-terminal domain
PF00570   HRDC domain
PF16124   RecQ zinc-binding

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005524   ATP binding  
GO:0003676   nucleic acid binding  
GO:0008026   ATP-dependent helicase activity  
GO:0006310   DNA recombination  

Metabolic Pathways

Homologous recombination (KEGG)
Fanconi anemia pathway (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
440 940 4cdg (A) 644 1159 45.00 0 1 0.855343 -0.3
448 1035 2p6r (A) 7 673 17.00 0 1 0.370445 0.75
451 857 5lb3 (B) 16 434 40.00 0 1 0.73162 -0.67
674 799 3eaq (A) 228 353 29.00 0 1 0.496995 -0.99
1207 1279 2rhf (A) 756 823 24.00 0.72 1 0.474458 -1.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126644)

Species Accession Gene Product
Arabidopsis thaliana AT1G10930   ATP-dependent DNA helicase Q-like 4A
Arabidopsis thaliana AT1G60930   RECQ helicase L4B
Arabidopsis thaliana AT3G05740   ATP-dependent DNA helicase Q-like 1
Arabidopsis thaliana AT1G31360   mediator of RNA polymerase II transcription subunit 34
Arabidopsis thaliana AT4G35740   ATP-dependent DNA helicase Q-like 3
Babesia bovis BBOV_II005510   ATP-dependent DNA helicase, RecQ family protein
Babesia bovis BBOV_II000810   ATP-dependent DNA helicase, RecQ family protein
Brugia malayi Bm1_34870   ATP-dependent DNA helicase, RecQ family protein
Brugia malayi Bm1_04100   ATP-dependent DNA helicase, RecQ family protein
Brugia malayi Bm1_49360   Bloom's syndrome protein homolog
Candida albicans CaO19.5335   DNA helicase
Candida albicans CaO19.12795   DNA helicase
Caenorhabditis elegans CELE_F18C5.2   Protein WRN-1
Caenorhabditis elegans CELE_K02F3.12   Protein K02F3.12, isoform B
Caenorhabditis elegans CELE_T04A11.6   Protein HIM-6
Caenorhabditis elegans CELE_E03A3.2   Protein RCQ-5
Cryptosporidium hominis Chro.60507   DEAD/DEAH box helicase
Cryptosporidium parvum cgd6_4420   RecQ bloom helicase (RNA helicase+hrdc)
Dictyostelium discoideum DDB_G0268512   ATP-dependent DNA helicase RecQ family protein
Dictyostelium discoideum DDB_G0292130   ATP-dependent DNA helicase RecQ family protein
Dictyostelium discoideum DDB_G0272384   ATP-dependent DNA helicase RecQ family protein
Drosophila melanogaster Dmel_CG6920   Bloom syndrome helicase ortholog
Drosophila melanogaster Dmel_CG4879   homolog of RecQ
Escherichia coli b3822   ATP-dependent DNA helicase
Echinococcus granulosus EgrG_001047300   bloom syndrome protein
Echinococcus granulosus EgrG_000859600   ATP dependent DNA helicase Q1
Echinococcus granulosus EgrG_001072500   ATP dependent DNA helicase Q5
Entamoeba histolytica EHI_028890   recQ family helicase, putative
Entamoeba histolytica EHI_023090   recQ family DNA helicase
Echinococcus multilocularis EmuJ_001072500   ATP dependent DNA helicase Q5
Echinococcus multilocularis EmuJ_000859600   ATP dependent DNA helicase Q1
Echinococcus multilocularis EmuJ_001047300   bloom syndrome protein
Giardia lamblia GL50803_9266   Sgs1 DNA helicase, putative
Homo sapiens ENSG00000165392   Werner syndrome, RecQ helicase-like
Homo sapiens ENSG00000004700   RecQ helicase-like
Homo sapiens ENSG00000108469   RecQ protein-like 5
Homo sapiens ENSG00000197299   Bloom syndrome, RecQ helicase-like
Leishmania braziliensis LbrM.24.1330   ATP-dependent DEAD/H DNA helicase recQ, putative
Leishmania donovani LdBPK_241590.1   ATP-dependent DEAD/H DNA helicase recQ, putative
Leishmania infantum LinJ.24.1590   ATP-dependent DEAD/H DNA helicase recQ, putative
Leishmania major LmjF.24.1530   ATP-dependent DEAD/H DNA helicase recQ, putative
Leishmania mexicana LmxM.24.1530   ATP-dependent DEAD/H DNA helicase recQ, putative
Loa Loa (eye worm) LOAG_11266   RecQ helicase
Loa Loa (eye worm) LOAG_11609   hypothetical protein
Loa Loa (eye worm) LOAG_11097   hypothetical protein
Loa Loa (eye worm) LOAG_00580   ATP-dependent DNA helicase
Loa Loa (eye worm) LOAG_00711   hypothetical protein
Mus musculus ENSMUSG00000030528   Bloom syndrome, RecQ helicase-like
Mus musculus ENSMUSG00000030243   RecQ protein-like
Mus musculus ENSMUSG00000031583   Werner syndrome homolog (human)
Mus musculus ENSMUSG00000020752   RecQ protein-like 5
Neospora caninum NCLIV_058800   hypothetical protein
Neospora caninum NCLIV_040350   hypothetical protein
Oryza sativa 4344306   Os07g0681600
Oryza sativa 4351098   Os11g0672700
Oryza sativa 4330923   Os02g0780800
Oryza sativa 4351234   Os11g0708600
Plasmodium berghei PBANKA_1014800   ADP-dependent DNA helicase RecQ, putative
Plasmodium berghei PBANKA_0819500   ATP-dependent DNA helicase Q1, putative
Plasmodium falciparum PF3D7_1429900   ADP-dependent DNA helicase RecQ
Plasmodium falciparum PF3D7_0918600   ATP-dependent DNA helicase Q1
Plasmodium knowlesi PKNH_1328800   ADP-dependent DNA helicase RecQ, putative
Plasmodium knowlesi PKNH_0716600   ATP-dependent DNA helicase Q1, putative
Plasmodium vivax PVX_085045   ADP-dependent DNA helicase RecQ, putative
Plasmodium yoelii PY07206   ATP-dependent DNA helicase-related
Plasmodium yoelii PY01271   ATP-dependent DNA helicase recQ-related
Saccharomyces cerevisiae YMR190C   Sgs1p
Schistosoma japonicum Sjp_0003760   ko:K03654 ATP-dependent DNA helicase RecQ, putative
Schistosoma japonicum Sjp_0132250   Bloom syndrome protein homolog, putative
Schistosoma mansoni Smp_056620   DNA helicase recq1
Schistosoma mansoni Smp_178900   blooms syndrome DNA helicase
Schistosoma mansoni Smp_129130   DNA helicase recq5
Schmidtea mediterranea mk4.005162.00   Werner Syndrome-like exonuclease
Schmidtea mediterranea mk4.001282.07   Werner Syndrome-like exonuclease
Schmidtea mediterranea mk4.002999.00   Bloom syndrome protein
Schmidtea mediterranea mk4.000882.02  
Schmidtea mediterranea mk4.001595.06   Bloom syndrome protein
Schmidtea mediterranea mk4.000541.10  
Schmidtea mediterranea mk4.000882.03   Putative ATP-dependent DNA helicase Q1
Schmidtea mediterranea mk4.000009.09   Putative dna helicase recq5
Schmidtea mediterranea mk4.038149.00   Bloom syndrome protein homolog
Trypanosoma brucei gambiense Tbg972.8.6870   ATP-dependent DEAD/H DNA helicase recQ, putative
Trypanosoma brucei Tb927.8.6690   ATP-dependent DEAD/H DNA helicase recQ, putative
Trypanosoma cruzi TcCLB.507989.40   ATP-dependent DEAD/H DNA helicase recQ, putative
Trypanosoma cruzi TcCLB.510063.20   ATP-dependent DEAD/H DNA helicase recQ, putative
Trypanosoma cruzi TcCLB.509243.60   ATP-dependent DEAD/H DNA helicase recQ, putative
Toxoplasma gondii TGME49_316300   ATP-dependent DNA helicase, RecQ family protein
Toxoplasma gondii TGME49_259250   ATP-dependent DNA helicase, RecQ family protein
Toxoplasma gondii TGME49_264840   ATP-dependent DNA helicase, RecQ family protein
Treponema pallidum TP0103   ATP-dependent DNA helicase
Theileria parva TP04_0501   hypothetical protein
Theileria parva TP02_0509   DNA helicase, putative
Trichomonas vaginalis TVAG_233770   DNA helicase recq, putative
Trichomonas vaginalis TVAG_255850   DNA helicase recq, putative
Trichomonas vaginalis TVAG_486790   DNA helicase recq1, putative

Essentiality

Tbg972.8.6870 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6690 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6690 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.6690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.6690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3822 Escherichia coli non-essential goodall
CELE_F18C5.2 Caenorhabditis elegans larval arrest wormbase
PBANKA_0819500 Plasmodium berghei Dispensable plasmo
PBANKA_1014800 Plasmodium berghei Slow plasmo
TGME49_264840 Toxoplasma gondii Essentiality uncertain sidik
TGME49_316300 Toxoplasma gondii Essentiality uncertain sidik
TGME49_259250 Toxoplasma gondii Essentiality uncertain sidik
TGME49_264840 Toxoplasma gondii Probably non-essential sidik
TGME49_316300 Toxoplasma gondii Probably non-essential sidik
TGME49_259250 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens Bloom syndrome, RecQ helicase-like Compounds References
Homo sapiens RecQ helicase-like Compounds References
Homo sapiens Werner syndrome, RecQ helicase-like Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Tbg972.8.6870 (Trypanosoma brucei gambiense), ATP-dependent DEAD/H DNA helicase recQ, putative
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