Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1095 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1228 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2625 | 0.2529 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.1095 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0128 | 0.0128 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.1095 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1095 | 0.1095 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2866 | 0.2866 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1095 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1028 | 0.0911 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.1095 | 0.098 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1228 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1228 | 0.1228 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1095 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1351 | 0.4014 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1095 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1228 | 0.1228 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1228 | 0.1114 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1228 | 0.2794 |
Brugia malayi | Inositol-1 | 0.0036 | 0.1095 | 0.2401 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2625 | 0.2529 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0835 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.1095 | 0.3255 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1187 | 0.2673 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.1095 | 0.098 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.3653 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.1095 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.1095 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.1095 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1192 | 0.3541 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1228 | 0.1114 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3366 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1028 | 0.0911 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.1095 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1479 | 0.4395 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0835 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.1095 | 0.1095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.