Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | low-density lipoprotein receptor (ldl) | 0.0006 | 0.0303 | 0.024 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0006 | 0.0303 | 0.024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4439 | 1 |
Onchocerca volvulus | 0.0035 | 0.4439 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.1608 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | low-density lipoprotein receptor (ldl) | 0.0006 | 0.0303 | 0.024 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0711 | 0.0651 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4722 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.1608 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0994 | 0.1671 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4439 | 0.4403 |
Schistosoma mansoni | low-density lipoprotein receptor (ldl) | 0.0006 | 0.0303 | 0.024 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0191 | 0.0127 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.1014 | 0.1718 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0711 | 0.0924 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8876 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0711 | 0.0924 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4439 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0711 | 0.0924 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0006 | 0.0303 | 0.024 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0006 | 0.0303 | 0.024 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4722 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0711 | 0.0924 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.