Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | EYA transcriptional coactivator and phosphatase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 26.9 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.5 % |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0808 | 0.0808 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1083 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0808 | 0.0808 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0902 | 0.8293 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | lipase | 0.0021 | 0 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.3127 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1083 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Toxoplasma gondii | lipase | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.1429 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0894 | 0.8221 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Trypanosoma brucei | lipase domain protein, putative | 0.1083 | 1 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0106 | 0.0808 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Trypanosoma brucei | lipase domain protein, putative | 0.1083 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1083 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1083 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1083 | 1 | 1 |
Toxoplasma gondii | lipase | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.1083 | 1 | 1 | |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.3127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0808 | 0.0808 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Loa Loa (eye worm) | lipase | 0.1083 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 1 |
Toxoplasma gondii | lipase | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | lipase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1083 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 0.3127 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.3127 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1083 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0185 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.