Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Brugia malayi | Tubulin alpha-2 chain | 0.0018 | 0.0159 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.009 | 0.0762 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.001 | 0.0023 | 0.0191 |
Loa Loa (eye worm) | alpha-tubulin | 0.0018 | 0.0159 | 0.1347 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0018 | 0.0159 | 0.1347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.075 | 0.0729 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0018 | 0.0159 | 0.0137 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0018 | 0.0159 | 0.1178 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0018 | 0.0159 | 0.1178 |
Schistosoma mansoni | kinesin eg-5 | 0.0082 | 0.118 | 0.1337 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0018 | 0.0159 | 0.1178 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0018 | 0.0159 | 0.1347 |
Echinococcus granulosus | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Entamoeba histolytica | kinesin, putative | 0.0082 | 0.118 | 1 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0014 | 0.009 | 0.0762 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.075 | 0.0729 |
Echinococcus granulosus | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Schistosoma mansoni | tubulin subunit alpha | 0.0018 | 0.0159 | 0.0158 |
Trypanosoma brucei | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0018 | 0.0159 | 0.1178 |
Giardia lamblia | Alpha-tubulin | 0.0018 | 0.0159 | 0.1178 |
Echinococcus granulosus | tubulin subunit TubB | 0.0018 | 0.0159 | 0.0137 |
Plasmodium falciparum | kinesin-5 | 0.0082 | 0.118 | 1 |
Schistosoma mansoni | alpha tubulin | 0.0018 | 0.0159 | 0.0158 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0018 | 0.0159 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0014 | 0.009 | 0.0762 |
Schistosoma mansoni | tubulin subunit alpha | 0.0018 | 0.0159 | 0.0158 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0018 | 0.0159 | 0.0137 |
Plasmodium vivax | kinesin-5 | 0.0082 | 0.118 | 1 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0018 | 0.0159 | 0.0137 |
Schistosoma mansoni | alpha tubulin | 0.0018 | 0.0159 | 0.0158 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.001 | 0.0023 | 0.0191 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.001 | 0.0023 | 0.0191 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0018 | 0.0159 | 0.1347 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.075 | 0.084 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0082 | 0.118 | 1 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0018 | 0.0159 | 0.1178 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.075 | 0.6356 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0014 | 0.009 | 0.494 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0018 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0159 | 0.1347 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0082 | 0.118 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0549 | 0.8683 | 1 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Giardia lamblia | Kinesin-5 | 0.0082 | 0.118 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.001 | 0.0023 | 0.0191 |
Plasmodium falciparum | alpha tubulin 1 | 0.0018 | 0.0159 | 0.1178 |
Schistosoma mansoni | alpha tubulin | 0.0018 | 0.0159 | 0.0158 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0018 | 0.0159 | 0.0158 |
Echinococcus granulosus | alpha tubulin | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.075 | 0.0729 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0018 | 0.0159 | 0.1178 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0013 | 0.0069 | 0.0585 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0018 | 0.0159 | 0.1178 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.075 | 0.084 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0018 | 0.0159 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0018 | 0.0159 | 0.0137 |
Trypanosoma brucei | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0018 | 0.0159 | 0.0137 |
Trypanosoma brucei | alpha tubulin | 0.0018 | 0.0159 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0018 | 0.0159 | 0.1347 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0013 | 0.0069 | 0.3406 |
Loa Loa (eye worm) | tubulin beta chain | 0.001 | 0.0023 | 0.0191 |
Giardia lamblia | Alpha-tubulin | 0.0018 | 0.0159 | 0.1178 |
Loa Loa (eye worm) | BEN-1 protein | 0.001 | 0.0023 | 0.0191 |
Brugia malayi | Tubulin alpha chain | 0.0018 | 0.0159 | 0.1178 |
Echinococcus granulosus | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | hypothetical protein | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | kinesin family 1 | 0.0631 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0069 | 0.0585 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0018 | 0.0159 | 0.0137 |
Brugia malayi | alpha-tubulin | 0.0018 | 0.0159 | 0.1178 |
Echinococcus granulosus | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0018 | 0.0159 | 0.0137 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.001 | 0.0023 | 0.0191 |
Brugia malayi | tubulin alpha-2 chain | 0.0018 | 0.0159 | 0.1178 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0018 | 0.0159 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0018 | 0.0159 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0018 | 0.0159 | 0.0137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.075 | 0.084 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0014 | 0.009 | 0.0762 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.075 | 0.0729 |
Brugia malayi | tubulin alpha chain - mouse | 0.0018 | 0.0159 | 0.1178 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.075 | 0.6285 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Leishmania major | alpha tubulin | 0.0018 | 0.0159 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0018 | 0.0159 | 0.0137 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0018 | 0.0159 | 0.0137 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0018 | 0.0159 | 0.0137 |
Loa Loa (eye worm) | beta-tubulin | 0.001 | 0.0023 | 0.0191 |
Brugia malayi | Kinesin motor domain containing protein | 0.0082 | 0.118 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0018 | 0.0159 | 0.1178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.