Detailed information for compound 1353436

Basic information

Technical information
  • TDR Targets ID: 1353436
  • Name: 4-[[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl) sulfonylamino]methyl]-N-(3,5-dimethylphenyl)c yclohexane-1-carboxamide
  • MW: 497.65 | Formula: C27H35N3O4S
  • H donors: 2 H acceptors: 4 LogP: 3.74 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCC(CC1)CNS(=O)(=O)c1ccc2c(c1)CC(N2C(=O)C)C)Nc1cc(C)cc(c1)C
  • InChi: 1S/C27H35N3O4S/c1-17-11-18(2)13-24(12-17)29-27(32)22-7-5-21(6-8-22)16-28-35(33,34)25-9-10-26-23(15-25)14-19(3)30(26)20(4)31/h9-13,15,19,21-22,28H,5-8,14,16H2,1-4H3,(H,29,32)
  • InChiKey: OGBLVZQTIRDRAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[(1-acetyl-2-methyl-indolin-5-yl)sulfonylamino]methyl]-N-(3,5-dimethylphenyl)cyclohexane-1-carboxamide
  • 4-[[(1-acetyl-2-methyl-5-indolinyl)sulfonylamino]methyl]-N-(3,5-dimethylphenyl)-1-cyclohexanecarboxamide
  • N-(3,5-dimethylphenyl)-4-[[(1-ethanoyl-2-methyl-2,3-dihydroindol-5-yl)sulfonylamino]methyl]cyclohexane-1-carboxamide
  • E589-2980
  • NCGC00123100-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.4849 0.6457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1061 0.0916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.6612 0.6209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.6091 0.8002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3046 0.3713
Giardia lamblia GTOR 0.0054 0.751 0.5
Brugia malayi TAR-binding protein 0.0068 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.1061 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.751 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.5019 0.6491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.6612 0.6209
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.5024 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.5533 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3046 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1061 0.0916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.6612 0.6209
Loa Loa (eye worm) RNA binding protein 0.0068 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.5525 0.7204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.6612 0.6209
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.1061 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3038 0.3702
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.1837 0.2447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3547 0.4418
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.4849 0.9652
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.5533 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1061 0.0916
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.5525 0.7204
Trichomonas vaginalis rotamase, putative 0.0039 0.4849 0.6252
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.751 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.4849 0.6457
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3605 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1061 0.0916
Brugia malayi RNA recognition motif domain containing protein 0.0068 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.6612 0.6209
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.5019 0.4427
Echinococcus granulosus expressed protein 0.004 0.5019 0.4427
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3046 0.3713
Schistosoma mansoni rotamase 0.004 0.5019 0.4427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3038 0.3702
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.5533 0.7367
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.751 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.6612 0.6209
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.751 1
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.5525 0.7204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.6612 0.6209
Loa Loa (eye worm) TAR-binding protein 0.0068 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.751 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3038 0.3702
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.751 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.6612 0.6209
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.5019 0.4427
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.1061 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.4106 0.5205
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.4849 0.6457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3605 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.4315 0.5501
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Echinococcus multilocularis tar DNA binding protein 0.0068 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.751 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.2396 0.319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.5525 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.751 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.751 0.7214
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.751 0.7214
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3547 0.4418
Schistosoma mansoni tar DNA-binding protein 0.0068 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.1061 0.1413
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.1061 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.5024 0.6498
Echinococcus multilocularis expressed protein 0.004 0.5019 0.4427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.751 0.7214
Trichomonas vaginalis rotamase, putative 0.004 0.5019 0.6491
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.751 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.751 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3605 0.4499
Echinococcus granulosus tar DNA binding protein 0.0068 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.751 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.751 0.7214
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.1061 0.1413
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.6612 0.6209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3046 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.5525 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1061 0.0916
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.4849 0.6457
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.751 0.7214

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6451 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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