Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Brugia malayi | Matrixin family protein | 0.1253 | 0.1206 | 0.0726 |
Brugia malayi | Matrixin family protein | 0.1253 | 0.1206 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.1655 | 0.2258 | 0.2357 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 0.1206 | 0.0726 |
Loa Loa (eye worm) | matrixin family protein | 0.3541 | 0.719 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1599 | 0.211 | 0.5571 |
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.1655 | 0.2258 | 0.2357 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1253 | 0.1206 | 0.0726 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.4615 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.113 | 0.0884 | 0.2335 |
Onchocerca volvulus | 0.1253 | 0.1206 | 0.0752 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1942 | 0.3008 | 0.7942 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.224 | 0.3788 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.113 | 0.0884 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.2502 | 0.4473 | 0.5789 |
Onchocerca volvulus | Matrilysin homolog | 0.1253 | 0.1206 | 0.0752 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.113 | 0.0884 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 0.1206 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.1655 | 0.2258 | 0.2357 |
Mycobacterium ulcerans | zinc metalloprotease | 0.224 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.111 | 0.0831 | 0.0145 |
Toxoplasma gondii | peptidase family M13 protein | 0.224 | 0.3788 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.224 | 0.3788 | 0.4727 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.224 | 0.3788 | 0.4727 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.2502 | 0.4473 | 0.5789 |
Onchocerca volvulus | Matrilysin homolog | 0.3016 | 0.5818 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.2327 | 0.4016 | 0.6387 |
Brugia malayi | Matrixin family protein | 0.3541 | 0.719 | 1 |
Onchocerca volvulus | 0.1599 | 0.211 | 0.2565 | |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.113 | 0.0884 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.224 | 0.3788 | 0.4727 |
Brugia malayi | Hemopexin family protein | 0.1599 | 0.211 | 0.2127 |
Mycobacterium leprae | probable zinc metalloprotease | 0.224 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.1694 | 0.236 | 0.2515 |
Loa Loa (eye worm) | matrixin family protein | 0.2327 | 0.4016 | 0.508 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1655 | 0.2258 | 0.2357 |
Brugia malayi | Peptidase family M13 containing protein | 0.224 | 0.3788 | 0.4727 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.224 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.224 | 0.3788 | 0.4727 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1655 | 0.2258 | 0.2357 |
Brugia malayi | Matrixin family protein | 0.1253 | 0.1206 | 0.0726 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.113 | 0.0884 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.1655 | 0.2258 | 0.2357 |
Brugia malayi | Matrixin family protein | 0.1253 | 0.1206 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.3008 | 0.3519 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = % | Uterotrophic and anti-uterotropic activities in immature rats at 0.5 mg/kg dose as %agonist:%antagonist = 17:26 | ChEMBL. | 6876081 |
Activity (functional) | = % | Uterotrophic and anti-uterotropic activities in immature rats at 5 mg/kg dose as %agonist:%antagonist = 34:60 | ChEMBL. | 6876081 |
Activity (functional) | = 0 % | Uterotrophic and anti-uterotropic activities in immature rats at 0.5 mg/kg dose as %agonist:%antagonist = 17:26 | ChEMBL. | 6876081 |
Activity (functional) | = 0 % | Uterotrophic and anti-uterotropic activities in immature rats at 5 mg/kg dose as %agonist:%antagonist = 34:60 | ChEMBL. | 6876081 |
Dose (functional) | ~ 1 mg kg-1 | Dose prevented implantation in two out of 3 rats | ChEMBL. | 6876081 |
MFED (functional) | = 5 mg kg-1 | Minimum fully effective dose that prevented implantation of eggs in three out of three rats (MFED) (antifertility) | ChEMBL. | 6876081 |
RBA (binding) | = 0.12 | Relative binding affinity determined by displacement of [3H]-estradiol relative to unlabeled estradiol | ChEMBL. | 6876081 |
RBA (binding) | = 0.12 | Relative binding affinity determined by displacement of [3H]-estradiol relative to unlabeled estradiol | ChEMBL. | 6876081 |
Reduction in movement (functional) | = 46 % | Sedative activity measured after ip administration to female mice and checked for their horizontal movement at a dose of 10 mg/Kg | ChEMBL. | 6876081 |
Reduction in movement (functional) | = 46 % | Sedative activity measured after ip administration to female mice and checked for their horizontal movement at a dose of 10 mg/Kg | ChEMBL. | 6876081 |
Reduction in movement (functional) | = 49 % | Sedative activity measured after ip administration to female mice and checked for their horizontal movement at a dose of 1 mg/Kg | ChEMBL. | 6876081 |
Reduction in movement (functional) | = 49 % | Sedative activity measured after ip administration to female mice and checked for their horizontal movement at a dose of 1 mg/Kg | ChEMBL. | 6876081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.