Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0177 | 0.2942 | 0.2942 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0148 | 0.2221 | 0.7549 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0199 | 0.351 | 0.351 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0177 | 0.2942 | 0.4124 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.7135 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0458 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0059 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0177 | 0.2942 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0458 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0177 | 0.2942 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0222 | 0.4078 | 1 |
Echinococcus multilocularis | geminin | 0.0344 | 0.7135 | 0.7135 |
Echinococcus granulosus | geminin | 0.0344 | 0.7135 | 0.7135 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0458 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0177 | 0.2942 | 0.2942 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.6223 | 0.8722 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0199 | 0.351 | 0.351 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.7135 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0177 | 0.2942 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 25.12 uM | Inhibition of GFP-fused Huntingtin protein Q103/Q25 mutant (unknown origin) expressed in human PC12 cells assessed as protection against cell death incubated for 48 hrs by Cytox-Glo based protease release HTT f3(pro) method | ChEMBL. | No reference |
AC50 (binding) | = 35.48 uM | Inhibition of GFP-fused Huntingtin protein Q103/Q25 mutant (unknown origin) expressed in human PC12 cells assessed as protection against cell death by measuring ATP level incubated for 48 hrs by ATPlite detection based HTT f2(ATP) assay | ChEMBL. | No reference |
AC50 (binding) | = 39.81 uM | Inhibition of GFP-fused Huntingtin protein Q103/Q25 mutant (unknown origin) expressed in human PC12 cells assessed as protection against cell death by measuring ATP level incubated for 48 hrs by ATPlite detection based HTT f1(ATP) assay | ChEMBL. | No reference |
Kd (binding) | Inhibition of PIP5K2C (unknown origin) | ChEMBL. | No reference | |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (Protease release). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471, 1688 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection in HTT Q25 expressing cells (ATP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471, 1688 ] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection confirmation (ATP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471, 1688 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.