Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0455 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0518 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0518 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0455 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0518 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0455 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0069 | 0.1333 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0518 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0135 | 0.1458 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0455 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0518 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0518 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0455 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0518 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0518 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0455 | 0.5 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0134 | 0.3523 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0455 | 0.8593 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.05 | 0.9658 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0518 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0018 | 0.0342 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0352 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0352 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0455 | 0.5 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0134 | 0.3523 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0518 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0352 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0455 | 0.8781 |
Echinococcus granulosus | lamin | 0.0033 | 0.0518 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0518 | 1 |
Onchocerca volvulus | 0.0033 | 0.0518 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0033 | 0.0518 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 223.8721 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.