Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0121 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0121 | 0.2791 | 0.2791 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3482 | 0.3482 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0029 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0029 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0121 | 0.2791 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0121 | 0.2791 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0121 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.193 | 0.193 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0361 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0361 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0029 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0029 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0361 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0121 | 0.2791 | 0.2791 |
Plasmodium falciparum | peptidase, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0093 | 0.193 | 0.193 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0121 | 0.2791 | 0.2791 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0121 | 0.2791 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0121 | 0.2791 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0121 | 0.2791 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0361 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3482 | 0.3482 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3482 | 0.3482 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0361 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.