Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2916 | 0.3342 |
Echinococcus granulosus | geminin | 0.0163 | 0.8726 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0707 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2916 | 0.2916 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0707 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2916 | 0.2916 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1017 | 0.1017 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1017 | 0.1017 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2916 | 0.2916 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0707 | 0.081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2916 | 0.3342 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0707 | 0.081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2916 | 0.3342 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2916 | 0.2916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2916 | 0.3342 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2916 | 0.2755 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2916 | 0.3342 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1017 | 0.1017 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0707 | 0.0707 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.8726 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2916 | 0.2916 |
Echinococcus multilocularis | geminin | 0.0163 | 0.8726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2916 | 0.2916 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2916 | 0.2755 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0707 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0707 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1017 | 0.1017 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.8726 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 4.6109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.