Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0022 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kon (binding) | = 26000 M-1 s-1 | Inhibition of human leukocyte elastase II (HLE-II) as second order rate constant | ChEMBL. | No reference |
k_on (binding) | = 26000 M-1 s-1 | Inhibition of human leukocyte elastase II (HLE-II) as second order rate constant | ChEMBL. | No reference |
pKa | = 6 | pKa value of the compound was determined | ChEMBL. | No reference |
T1/2 | = 24 hr | Chemical half-life of the compound was evaluated at 37 degree C expressed as stability towards hydrolysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.