Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | alkaline phosphatase, placental-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0188 | 0.0228 | 0.035 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0188 | 0.0228 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0188 | 0.0228 | 0.9158 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0188 | 0.0228 | 0.7672 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.091 | 0.2131 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0196 | 0.0249 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1063 | 0.2536 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.2487 | 0.6293 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2676 | 0.679 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1063 | 0.2536 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0188 | 0.0228 | 0.0098 |
Giardia lamblia | Telomerase catalytic subunit | 0.1063 | 0.2536 | 0.5 |
Brugia malayi | hypothetical protein | 0.0188 | 0.0228 | 0.0098 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1063 | 0.2536 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2829 | 0.7195 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0196 | 0.0249 | 0.0456 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1063 | 0.2536 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0196 | 0.0249 | 0.0456 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2676 | 0.679 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0196 | 0.0249 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.0249 | 1 |
Echinococcus multilocularis | 0.0188 | 0.0228 | 0.035 | |
Brugia malayi | SWIRM domain containing protein | 0.0188 | 0.0228 | 0.0098 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0188 | 0.0228 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Schistosoma mansoni | amine oxidase | 0.0188 | 0.0228 | 0.9158 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1063 | 0.2536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0188 | 0.0228 | 0.9158 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0188 | 0.0228 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0188 | 0.0228 | 0.9158 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.025 | 0.039 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1063 | 0.2536 | 0.5 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.0249 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0196 | 0.0249 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0196 | 0.0249 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1063 | 0.2536 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0188 | 0.0228 | 0.7672 |
Echinococcus granulosus | alkaline phosphatase | 0.0196 | 0.0249 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0228 | 1 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0196 | 0.0249 | 0.0456 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 66.9 um | PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 518 ] | ChEMBL. | No reference |
IC50 (functional) | = 2.01 um | PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 1512, 518 ] | ChEMBL. | No reference |
IC50 (functional) | = 23.1 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay<not set>. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] | ChEMBL. | No reference |
IC50 (functional) | = 23.4 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] | ChEMBL. | No reference |
IC50 (functional) | = 30.3 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] | ChEMBL. | No reference |
IC50 (functional) | = 47.9 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.