Detailed information for compound 137098

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 500.544 | Formula: C25H32N4O7
  • H donors: 5 H acceptors: 5 LogP: 2.61 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H]([C@H](C(=O)NCC(C(=O)NO)NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C
  • InChi: 1S/C25H32N4O7/c1-3-17(2)21(28-25(33)36-16-19-12-8-5-9-13-19)23(31)26-14-20(22(30)29-34)27-24(32)35-15-18-10-6-4-7-11-18/h4-13,17,20-21,34H,3,14-16H2,1-2H3,(H,26,31)(H,27,32)(H,28,33)(H,29,30)/t17-,20?,21-/m1/s1
  • InChiKey: XJVDLTPBZMWREW-UBCDJDFNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tolloid-like 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Bone morphogenetic protein 1 homolog precursor, putative Get druggable targets OG5_130155 All targets in OG5_130155
Schistosoma japonicum IPR000859,CUB,domain-containing Get druggable targets OG5_130155 All targets in OG5_130155
Schistosoma japonicum ko:K09608 tolloid-like protein 1, putative Get druggable targets OG5_130155 All targets in OG5_130155
Loa Loa (eye worm) AStacin protease Get druggable targets OG5_130155 All targets in OG5_130155
Loa Loa (eye worm) bone morphogenetic protein 1b Get druggable targets OG5_130155 All targets in OG5_130155
Echinococcus granulosus Tolloid protein 1 Get druggable targets OG5_130155 All targets in OG5_130155
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) Get druggable targets OG5_130155 All targets in OG5_130155
Echinococcus multilocularis Tolloid protein 1 Get druggable targets OG5_130155 All targets in OG5_130155
Schistosoma japonicum Iroquois-class homeodomain protein IRX-1, putative Get druggable targets OG5_130155 All targets in OG5_130155
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130155 All targets in OG5_130155
Schistosoma japonicum Tolloid-like protein 2 precursor, putative Get druggable targets OG5_130155 All targets in OG5_130155
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0178 0.1275
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0579 0.5923
Echinococcus granulosus importin subunit beta 1 0.0031 0.0473 0.0427
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0188 0.0297
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.118 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.194 0.1901
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0473 0.0427
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0048 0.0319
Echinococcus multilocularis geminin 0.0188 0.5434 0.5412
Schistosoma mansoni hypothetical protein 0.0026 0.0311 0.0311
Echinococcus granulosus GPCR family 2 0.0018 0.006 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.1322 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0018 0.0057 0.0071
Brugia malayi hypothetical protein 0.0037 0.0672 0.1064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.108 0.1037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.006 0.0012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.1066 0.1066
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.2309 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0473 0.3338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0944 0.09
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.3172 0.8849
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3651 0.3651
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0034 0.0579 0.685
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0944 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.0188 0.1512
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.1295 0.1295
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0579 0.0533
Entamoeba histolytica hypothetical protein 0.0041 0.0792 0.2882
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0944 1
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.1322 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1103 0.106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.4299 0.4272
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0053 0.118 0.8885
Schistosoma mansoni hypothetical protein 0.0018 0.006 0.006
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0188 0.0297
Plasmodium falciparum thioredoxin reductase 0.0051 0.1103 0.8333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.006 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.108 0.1037
Plasmodium vivax glutathione reductase, putative 0.0051 0.1103 0.8333
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1103 0.8333
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.1322 1
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0723 0.1145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1295 0.1295
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0579 0.4166
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.3172 0.8849
Entamoeba histolytica hypothetical protein 0.0041 0.0792 0.2882
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0188 0.0045
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0579 0.5923
Plasmodium vivax importin-beta 2, putative 0.0031 0.0473 0.3527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0034 0.0579 0.0579
Brugia malayi RNA, U transporter 1 0.0088 0.2289 0.3623
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0188 0.1095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0048 0.0284
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.118 0.1137
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0188 0.1512
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.3583 1
Mycobacterium tuberculosis Probable reductase 0.0116 0.3172 0.8849
Brugia malayi Fibulin-1 precursor 0.0018 0.0057 0.0091
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0034 0.0579 0.0579
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1103 0.8284
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0311 0.0264
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0823 0.6194
Schistosoma mansoni hypothetical protein 0.0041 0.0792 0.0792
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0048 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.108 0.108
Entamoeba histolytica hypothetical protein 0.0041 0.0792 0.2882
Brugia malayi Thioredoxin reductase 0.0051 0.1103 0.1747
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0048 0.0076
Loa Loa (eye worm) hypothetical protein 0.0089 0.2309 0.2309
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.4438 0.7026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.3583 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.118 0.1137
Plasmodium falciparum glutathione reductase 0.0018 0.0048 0.0284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0792 0.0748
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0823 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0287 0.1875
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0178 0.1019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0188 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0048 0.0319
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0077 0.194 0.194
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0579 0.5923
Loa Loa (eye worm) hypothetical protein 0.0034 0.0579 0.0579
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0473 0.3338
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.3583 1
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1103 0.1103
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0579 0.0533
Leishmania major trypanothione reductase 0.0051 0.1103 0.8284
Schistosoma mansoni importin beta-1 0.0031 0.0473 0.0473
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0178 0.1019
Plasmodium falciparum thioredoxin reductase 0.0018 0.0048 0.0284
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0188 0.1512
Loa Loa (eye worm) hypothetical protein 0.0018 0.006 0.006
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0057 0.0091
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0178 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0188 0.0297
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0188 0.0495
Schistosoma mansoni hypothetical protein 0.0018 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0018 0.006 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.108 0.108
Schistosoma mansoni hypothetical protein 0.0188 0.5434 0.5434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.3651 0.3651
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0188 0.0028
Plasmodium falciparum glutathione reductase 0.0051 0.1103 0.8333
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0178 1
Entamoeba histolytica hypothetical protein 0.0041 0.0792 0.2882
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0792 0.0792
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.108 0.171
Loa Loa (eye worm) glutathione reductase 0.0051 0.1103 0.1103
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.2309 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.1322 1
Echinococcus granulosus tar DNA binding protein 0.0131 0.3651 0.362
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.194 0.194
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0579 0.0917
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.006 0.0012
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0056 0.1252 0.1252
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0579 0.1881
Brugia malayi hypothetical protein 0.0058 0.1322 0.2093
Schistosoma mansoni hypothetical protein 0.0039 0.0723 0.0723
Loa Loa (eye worm) acetyltransferase 0.0156 0.4438 0.4438
Loa Loa (eye worm) RNA binding protein 0.0131 0.3651 0.3651
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3651 0.3651
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0188
Echinococcus multilocularis snurportin 1 0.0332 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0188 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3651 0.3651
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0048 0.0284
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0025 0.0287 0.0512
Brugia malayi TAR-binding protein 0.0131 0.3651 0.578
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0287 0.2666
Toxoplasma gondii calcium binding egf domain-containing protein 0.0018 0.0057 0.0071
Echinococcus granulosus laminin 0.0018 0.0057 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.118 0.118
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.118 0.1868
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0311 0.0264
Echinococcus granulosus geminin 0.0188 0.5434 0.5412
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1103 0.106
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0053 0.118 0.3273
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0823 0.3026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0188 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3651 0.3651
Brugia malayi glutathione reductase 0.0051 0.1103 0.1747
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0579 0.0533
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0579 0.4166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.108 0.1037
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3651 0.3651
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0178 0.1275
Trypanosoma brucei trypanothione reductase 0.0051 0.1103 0.8284
Echinococcus granulosus Tolloid protein 1 0.0056 0.1252 0.1209
Brugia malayi Importin beta-1 subunit 0.0031 0.0473 0.0749
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0178 0.143
Echinococcus granulosus ubiquitin specific protease 41 0.0034 0.0579 0.0533
Leishmania major hypothetical protein, conserved 0.0058 0.1322 1
Echinococcus multilocularis tar DNA binding protein 0.0131 0.3651 0.362
Echinococcus multilocularis ubiquitin specific protease 41 0.0034 0.0579 0.0533
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.3172 0.8849
Leishmania major importin beta-1 subunit, putative 0.0025 0.0287 0.1875
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.1322 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.108 0.1037
Schistosoma mansoni hypothetical protein 0.0188 0.5434 0.5434
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0188 0.1512
Schistosoma mansoni hypothetical protein 0.0332 1 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.006 0.0095
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0178 0.0468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0031 0.0473 0.0473
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.3172 0.8849
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0048 0.0319
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0178 0.1019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.1322 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.108 0.108
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0056 0.1252 0.1252
Schistosoma mansoni hypothetical protein 0.0018 0.006 0.006
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0579 0.4166
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0188
Brugia malayi hypothetical protein 0.0041 0.0792 0.1254
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.4438 0.4438
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0188 0.1512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0188 0.0495
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.194 0.1901
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0579 0.4166
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0207 0.0207
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0792 0.0748
Toxoplasma gondii thioredoxin reductase 0.0051 0.1103 0.8284
Onchocerca volvulus 0.0022 0.0188 0.0968
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.3172 0.8793
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1295 0.205
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0215 0.6317 0.6317
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0048 0.0104
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0473 0.3338
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0048 0.223
Plasmodium falciparum importin beta, putative 0.0031 0.0473 0.3527
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.3172 0.8849
Brugia malayi follicle stimulating hormone receptor 0.0215 0.6317 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0188 0.1512
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0018 0.0057 0.0057
Brugia malayi RNA binding protein 0.0131 0.3651 0.578
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.118 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0188 0.1512
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0178 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0944 0.7034
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.1322 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.194 0.3071
Loa Loa (eye worm) TAR-binding protein 0.0131 0.3651 0.3651
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.4438 0.4411
Loa Loa (eye worm) hypothetical protein 0.0022 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0058 0.1322 0.1322
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0944 0.7118
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.3651 0.578
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0178 0.143
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0178 0.1019
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0188 0.1512
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0188 0.1095
Loa Loa (eye worm) AStacin protease 0.0035 0.0591 0.0591
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0287 0.2666
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.3583 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0011
Echinococcus multilocularis fibrillin 1 0.0018 0.0057 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0944 0.7034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1103 0.3058
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0048 0.0284
Echinococcus multilocularis Tolloid protein 1 0.0056 0.1252 0.1209
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.006 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.108 0.108
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0053 0.118 0.118
Echinococcus multilocularis laminin 0.0018 0.0057 0.0009
Echinococcus multilocularis GPCR, family 2 0.0018 0.006 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0287 0.2666
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0579 0.0533
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0188 0.1095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1295 0.205
Onchocerca volvulus 0.0077 0.194 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.061 uM Inhibitory effect against Procollagen C-terminal proteinase ChEMBL. 11086718
IC50 (binding) = 0.061 uM Inhibitory effect against Procollagen C-terminal proteinase ChEMBL. 11086718

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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