Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0665 | 0.0398 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0141 | 0.3343 | 0.7094 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0381 | 0.0282 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0241 | 0.6377 | 0.6377 |
Giardia lamblia | CDC8 | 0.0141 | 0.3343 | 0.4908 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.016 | 0.391 | 1 |
Onchocerca volvulus | 0.0182 | 0.4598 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0381 | 0.0105 |
Brugia malayi | hypothetical protein | 0.0076 | 0.1369 | 0.2524 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0381 | 0.0237 |
Plasmodium vivax | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.8402 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.4615 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Onchocerca volvulus | 0.016 | 0.391 | 0.8407 | |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.3343 | 0.3152 |
Brugia malayi | hypothetical protein | 0.0182 | 0.4598 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0141 | 0.3343 | 0.494 |
Leishmania major | thymidylate kinase-like protein | 0.0141 | 0.3343 | 0.4615 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 0.391 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 0.5621 |
Echinococcus granulosus | thymidylate synthase | 0.016 | 0.391 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.3942 |
Toxoplasma gondii | thymidylate kinase | 0.0141 | 0.3343 | 0.8402 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.016 | 0.391 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 0.3736 |
Giardia lamblia | Thymidine kinase | 0.0241 | 0.6377 | 1 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0665 | 0.1064 |
Schistosoma mansoni | thymidylate kinase | 0.0141 | 0.3343 | 0.3152 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.1265 | 0.2284 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0141 | 0.3343 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1265 | 0.2284 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 0.5621 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.016 | 0.391 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.016 | 0.391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4598 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.016 | 0.391 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0361 | 1 | 1 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0665 | 0.1064 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.3343 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0076 | 0.1369 | 0.1111 |
Loa Loa (eye worm) | thymidylate synthase | 0.016 | 0.391 | 0.8407 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0141 | 0.3343 | 0.5 |
Echinococcus granulosus | thymidylate kinase | 0.0141 | 0.3343 | 0.8439 |
Echinococcus multilocularis | thymidylate kinase | 0.0141 | 0.3343 | 0.8439 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0381 | 0.0282 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.3942 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.3343 |
Mycobacterium ulcerans | thymidylate synthase | 0.016 | 0.391 | 1 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0362 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0381 | 0.0105 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0141 | 0.3343 | 0.4615 |
Leishmania major | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0141 | 0.3343 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.0141 | 0.3343 | 0.7094 |
Entamoeba histolytica | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0241 | 0.6377 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0141 | 0.3343 | 0.3152 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0141 | 0.3343 | 0.7769 |
Brugia malayi | thymidylate kinase | 0.0141 | 0.3343 | 0.7094 |
Brugia malayi | thymidylate synthase | 0.016 | 0.391 | 0.8407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.1014 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.