Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0223 | 0.1568 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1317 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0223 | 0.1568 | 0.5 |
Onchocerca volvulus | 0.0223 | 0.1568 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0188 | 0.0188 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1317 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0223 | 0.1568 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.017 | 0.017 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0223 | 0.1568 | 0.1568 |
Echinococcus granulosus | acetylcholinesterase | 0.1317 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0188 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.7396 | 0.7396 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0223 | 0.1568 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.017 | 0.017 |
Onchocerca volvulus | 0.0223 | 0.1568 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0317 | 0.0317 |
Echinococcus multilocularis | acetylcholinesterase | 0.1317 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1317 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0223 | 0.1568 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.017 | 0.017 |
Brugia malayi | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0317 | 0.0317 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0188 | 0.0188 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0223 | 0.1568 | 0.1568 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1317 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1568 | 0.1568 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.1317 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1568 | 0.1568 |
Onchocerca volvulus | 0.0223 | 0.1568 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1317 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | carboxylesterase | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0317 | 0.0317 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0188 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1568 | 0.1568 |
Schistosoma mansoni | acetylcholinesterase | 0.0223 | 0.1568 | 0.1568 |
Echinococcus granulosus | neuroligin | 0.0223 | 0.1568 | 0.1568 |
Onchocerca volvulus | 0.0223 | 0.1568 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1317 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0188 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0223 | 0.1568 | 0.1568 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1317 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | carboxylesterase | 0.0223 | 0.1568 | 0.1568 |
Echinococcus granulosus | acetylcholinesterase | 0.1317 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0188 | 0.0188 |
Onchocerca volvulus | 0.0223 | 0.1568 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0223 | 0.1568 | 0.1568 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0188 | 0.0188 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1568 | 0.1568 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0223 | 0.1568 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0188 | 0.0188 |
Echinococcus granulosus | carboxylesterase 5A | 0.1317 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0223 | 0.1568 | 0.1568 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0223 | 0.1568 | 0.1568 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1568 | 0.1568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.99 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.