TDR Targets

Basic information

Technical information

TDR Targets ID: 1374463
Name: 3-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)-4 -fluoro-N-(4-propan-2-ylphenyl)benzamide
MW: 452.541 | Formula: C25H25FN2O3S
H donors: 1 H acceptors: 3 LogP: 4.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(c(c1)S(=O)(=O)N1CCc2c(C1)cccc2)F)Nc1ccc(cc1)C(C)C
InChi: 1S/C25H25FN2O3S/c1-17(2)18-7-10-22(11-8-18)27-25(29)20-9-12-23(26)24(15-20)32(30,31)28-14-13-19-5-3-4-6-21(19)16-28/h3-12,15,17H,13-14,16H2,1-2H3,(H,27,29)
InChiKey: PLLLNFLFRJFHJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)-4-fluoro-N-(4-isopropylphenyl)benzamide
K781-6952
NCGC00141887-01
Oprea1_266270

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	histone deacetylase 6	0.1208	0.9235	0.9233
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Leishmania major	hypothetical protein, conserved	0.0025	0.006	0.0039
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.0025	0.006	0.0039
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Schistosoma mansoni	histone deacetylase hda2	0.1233	0.9431	0.9429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0025	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0082	0.0503	0.0483
Trypanosoma brucei	histone deacetylase, putative	0.1208	0.9235	0.923
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0025	0.006	0.006
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0025	0.006	0.0039
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0025	0.006	0.0039
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0117	0.0117
Plasmodium falciparum	histone deacetylase, putative	0.1208	0.9235	0.9233
Leishmania major	cathepsin L-like protease	0.0077	0.0462	0.0442
Leishmania major	hypothetical protein, conserved	0.0025	0.006	0.0039
Echinococcus granulosus	histone deacetylase 6	0.1208	0.9235	0.9233
Schistosoma mansoni	hypothetical protein	0.0038	0.016	0.0139
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0025	0.006	0.0039
Brugia malayi	histone deacetylase 1 (HD1)	0.1306	1	1
Echinococcus granulosus	histone deacetylase 3	0.1306	1	1
Leishmania major	histone deacetylase, putative	0.1306	1	1
Trypanosoma cruzi	Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative	0.0025	0.006	0.0039
Echinococcus granulosus	histone deacetylase	0.1208	0.9235	0.9233
Echinococcus multilocularis	BRCA1 associated protein	0.0025	0.006	0.0039
Loa Loa (eye worm)	histone deacetylase 1	0.1306	1	1
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0025	0.006	0.006
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0025	0.006	0.0039
Loa Loa (eye worm)	fibroinase	0.002	0.0022	0.0022
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1306	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0022	0.0022
Leishmania major	histone deacetylase, putative	0.1306	1	1
Leishmania major	histone deacetylase, putative	0.1208	0.9235	0.9233
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.012	0.0799	0.0799
Toxoplasma gondii	histone deacetylase HDAC5	0.06	0.4516	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0503	0.0503
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.0025	0.006	0.0039
Echinococcus multilocularis	musashi	0.0033	0.0117	0.0096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0025	0.006	0.0039
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0025	0.006	0.006
Plasmodium vivax	histone deacetylase 2, putative	0.1208	0.9235	0.9233
Schistosoma mansoni	lamin	0.0033	0.0117	0.0096
Echinococcus granulosus	histone deacetylase 7	0.1208	0.9235	0.9233
Plasmodium vivax	histone deacetylase 1, putative	0.1306	1	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0022	0.0022
Plasmodium vivax	histone deacetylase, putative	0.06	0.4516	0.4504
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0025	0.006	0.0039
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0462	0.0442
Schistosoma mansoni	brca1-associated protein (brap2)	0.0025	0.006	0.0039
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Echinococcus granulosus	histone deacetylase 8	0.06	0.4516	0.4504
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Trypanosoma cruzi	Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative	0.0025	0.006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.012	0.0799	0.0799
Echinococcus multilocularis	histone deacetylase 6	0.1233	0.9431	0.9429
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0025	0.006	0.0039
Echinococcus granulosus	BRCA1 associated protein	0.0025	0.006	0.0039
Brugia malayi	Histone deacetylase family protein	0.1208	0.9235	0.9235
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1306	1	1
Plasmodium vivax	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0025	0.006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0038	0.016	0.016
Echinococcus granulosus	lamin dm0	0.0033	0.0117	0.0096
Schistosoma mansoni	brca1-associated protein (brap2)	0.0025	0.006	0.0039
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0038	0.016	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Echinococcus multilocularis	histone deacetylase 8	0.06	0.4516	0.4504
Entamoeba histolytica	histone deacetylase, putative	0.1306	1	1
Schistosoma mansoni	histone deacetylase hda2	0.06	0.4516	0.4504
Brugia malayi	BRCA1-associated protein 2 containing protein	0.0025	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0117	0.0117
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Schistosoma mansoni	histone deacetylase 1 2 3	0.06	0.4516	0.4504
Schistosoma mansoni	histone deacetylase 4 5	0.1208	0.9235	0.9233
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0022	0.0022
Loa Loa (eye worm)	ctsf protein	0.002	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.006	0.0039
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0025	0.006	0.006
Schistosoma mansoni	histone deacetylase	0.1306	1	1
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0025	0.006	0.0039
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Trypanosoma brucei	histone deacetylase 2	0.06	0.4516	0.4483
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Echinococcus multilocularis	lamin dm0	0.0033	0.0117	0.0096
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0462	0.0442
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0038	0.016	0.0139
Loa Loa (eye worm)	histone deacetylase 7A	0.1208	0.9235	0.9235
Echinococcus granulosus	histone deacetylase 6	0.1208	0.9235	0.9233
Echinococcus multilocularis	histone deacetylase	0.1208	0.9235	0.9233
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.0799	0.0799
Trypanosoma cruzi	histone deacetylase, putative	0.06	0.4516	0.4504
Brugia malayi	histone deacetylase 11	0.06	0.4516	0.4516
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0025	0.006	0.0039
Trypanosoma cruzi	histone deacetylase, putative	0.1208	0.9235	0.9233
Onchocerca volvulus	Histone deacetylase 10 homolog	0.06	0.4516	1
Leishmania major	cathepsin L-like protease	0.0077	0.0462	0.0442
Trypanosoma cruzi	histone deacetylase 1, putative	0.1306	1	1
Echinococcus granulosus	histone deacetylase 6	0.1233	0.9431	0.9429
Echinococcus multilocularis	GPCR, family 2	0.0038	0.016	0.0139
Loa Loa (eye worm)	cysteine protease	0.002	0.0022	0.0022
Schistosoma mansoni	histone deacetylase	0.1306	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.006	0.0039
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.016	0.016
Loa Loa (eye worm)	histone deacetylase 3	0.1306	1	1
Giardia lamblia	Histone deacetylase	0.1306	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0025	0.006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0633	0.4779	0.4779
Schistosoma mansoni	hypothetical protein	0.0038	0.016	0.0139
Toxoplasma gondii	Zn-finger in ubiquitin-hydrolases domain-containing protein	0.0025	0.006	0.0039
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.006	0.0039
Echinococcus granulosus	histone deacetylase 1	0.1306	1	1
Trypanosoma brucei	histone deacetylase 3	0.1208	0.9235	0.923
Trichomonas vaginalis	BRCA1-associated protein, putative	0.0025	0.006	0.0039
Toxoplasma gondii	histone deacetylase HDAC4	0.06	0.4516	0.4504
Plasmodium vivax	histone deacetylase, putative	0.1208	0.9235	0.9233
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.041	0.039
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0113
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.006	0.0039
Trypanosoma cruzi	histone deacetylase 1, putative	0.1306	1	1
Echinococcus multilocularis	lamin	0.0033	0.0117	0.0096
Brugia malayi	intermediate filament protein	0.0033	0.0117	0.0117
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0025	0.006	0.006
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0025	0.006	0.0039
Trypanosoma cruzi	Zn-finger in ubiquitin-hydrolases and other protein, putative	0.0025	0.006	0.0039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Schistosoma mansoni	hypothetical protein	0.0038	0.016	0.0139
Loa Loa (eye worm)	histone deacetylase 11	0.06	0.4516	0.4516
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0334	0.0314
Schistosoma mansoni	lamin	0.0033	0.0117	0.0096
Leishmania major	histone deacetylase, putative	0.1208	0.9235	0.9233
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0025	0.006	0.0039
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0117	0.0096
Trypanosoma cruzi	histone deacetylase, putative	0.06	0.4516	0.4504
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0025	0.006	0.0039
Loa Loa (eye worm)	hypothetical protein	0.1306	1	1
Toxoplasma gondii	histone deacetylase HDAC2	0.1306	1	1
Onchocerca volvulus		0.0033	0.0117	0.0213
Schistosoma mansoni	hypothetical protein	0.0038	0.016	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0608	0.4584	0.4584
Loa Loa (eye worm)	BRCA1-associated protein 2 containing protein	0.0025	0.006	0.006
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0025	0.006	0.0039
Onchocerca volvulus	Uncharacterized RING finger protein homolog	0.0025	0.006	0.0087
Echinococcus granulosus	GPCR family 2	0.0038	0.016	0.0139
Trypanosoma brucei	histone deacetylase 4	0.1208	0.9235	0.923
Echinococcus granulosus	lamin	0.0033	0.0117	0.0096
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0117	0.0117
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0025	0.006	0.0039
Echinococcus multilocularis	histone deacetylase 7	0.1208	0.9235	0.9233
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.1306	1	1
Leishmania major	cathepsin L-like protease	0.0077	0.0462	0.0442
Echinococcus multilocularis	histone deacetylase 6	0.1208	0.9235	0.9233
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.016	0.016
Trichomonas vaginalis	histone deacetylase, putative	0.1306	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.0462	0.0442
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.0462	0.0442
Trichomonas vaginalis	brca1-associated protein, putative	0.0025	0.006	0.0039
Brugia malayi	Cathepsin L-like precursor	0.002	0.0022	0.0022
Plasmodium falciparum	histone deacetylase 1	0.1306	1	1
Brugia malayi	Histone deacetylase 1	0.1306	1	1
Plasmodium falciparum	histone deacetylase 2	0.1208	0.9235	0.9233
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0025	0.006	0.0039
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0025	0.006	0.0039
Toxoplasma gondii	histone deacetylase HDAC3	0.1306	1	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0025	0.006	0.006
Schistosoma mansoni	histone deacetylase 4 5	0.1208	0.9235	0.9233
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.0799	0.0799
Loa Loa (eye worm)	hypothetical protein	0.06	0.4516	0.4516
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.016	0.016
Echinococcus multilocularis	histone deacetylase 1	0.1306	1	1
Echinococcus multilocularis	histone deacetylase 3	0.1306	1	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.016	0.0139
Loa Loa (eye worm)	histone deacetylase	0.1208	0.9235	0.9235
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.0462	0.0404
Trypanosoma cruzi	histone deacetylase, putative	0.1208	0.9235	0.9233
Toxoplasma gondii	histone deacetylase HDAC1	0.1208	0.9235	0.9233
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.006	0.0039
Trypanosoma brucei	histone deacetylase 1	0.1306	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.0503	0.0503
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0117	0.0117
Echinococcus granulosus	intermediate filament protein	0.0033	0.0117	0.0096
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.016	0.0139
Trypanosoma cruzi	histone deacetylase, putative	0.1208	0.9235	0.9233
Plasmodium falciparum	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0025	0.006	0.0039
Brugia malayi	Histone deacetylase family protein	0.1208	0.9235	0.9235
Onchocerca volvulus		0.0033	0.0117	0.0213
Loa Loa (eye worm)	hypothetical protein	0.002	0.0022	0.0022

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1496450

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1374463