Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.2517 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.2517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.607 | 0.6032 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.2517 | 0.5 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0024 | 0.2517 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.607 | 0.5371 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.2517 | 0.1187 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.2517 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0096 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.2517 | 0.2445 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0024 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1509 | 0.2486 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1509 | 0.2486 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.2517 | 0.1187 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0024 | 0.2517 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.2517 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.2517 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 0.2517 | 0.2445 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.2517 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.2517 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0024 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.607 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.2517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0096 | 0.0000000020559 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.2517 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.2517 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 0.2517 | 0.4147 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1509 | 0.2486 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0012 | 0.0096 | 0.0158 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0096 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2517 | 0.2445 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0024 | 0.2517 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0096 | 0.0381 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1509 | 0.2486 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1509 | 0.1427 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1509 | 0.1427 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.2517 | 0.1187 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 0.2517 | 0.4147 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0096 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 0.2517 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.