Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0545 | 0.1849 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0067 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0067 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0067 | 0.5 |
Brugia malayi | Hint module family protein | 0.0106 | 0.1858 | 0.6305 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0545 | 0.1849 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.2947 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.2947 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0285 | 0.6964 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.4677 | 0.4642 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4677 | 0.6716 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0067 | 0.0226 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.677 | 1 |
Onchocerca volvulus | 0.0043 | 0.0067 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0067 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0067 | 0.0096 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0067 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0067 | 0.5 | |
Echinococcus multilocularis | hedgehog | 0.0391 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0067 | 0.0226 |
Brugia malayi | Hint module family protein | 0.0106 | 0.1858 | 0.6305 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0067 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0067 | 0.0226 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0067 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4677 | 0.4642 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0067 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0067 | 0.0096 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0545 | 0.1849 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.2947 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0067 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0067 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0067 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0067 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0067 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0067 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0067 | 0.0226 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1858 | 0.6305 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1858 | 0.6305 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0067 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0067 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0067 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0545 | 0.1849 |
Onchocerca volvulus | 0.0043 | 0.0067 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0067 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4677 | 0.6716 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.