Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0681 | 0.1094 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0681 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0681 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0681 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1078 | 0.2052 |
Echinococcus multilocularis | 0.011 | 0.3324 | 1 | |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0044 | 0.0701 | 0.1143 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0051 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0086 | 0.2358 | 0.6881 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0681 | 0.1557 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0044 | 0.0701 | 0.1143 |
Echinococcus granulosus | Furin 1 | 0.0032 | 0.0232 | 0.0011 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0681 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0681 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0044 | 0.0701 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4373 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0681 | 0.1557 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0681 | 0.3031 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0681 | 0.3031 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0681 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0681 | 0.5 |
Echinococcus granulosus | furin | 0.0136 | 0.4373 | 1 |
Onchocerca volvulus | 0.0043 | 0.0681 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0681 | 0.5 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0059 | 0.1309 | 0.2995 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0681 | 0.1094 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0083 | 0.2246 | 0.652 |
Brugia malayi | proprotein convertase 2 | 0.0086 | 0.2358 | 0.514 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0681 | 0.5 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0032 | 0.0232 | 0.0011 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0136 | 0.4373 | 1 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0086 | 0.2358 | 0.514 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0681 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0681 | 0.5 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0136 | 0.4373 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0681 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0681 | 0.3031 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0083 | 0.2246 | 1 |
Onchocerca volvulus | 0.0043 | 0.0681 | 0.5 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0083 | 0.2246 | 1 |
Echinococcus multilocularis | Furin 1 | 0.0032 | 0.0232 | 0.0015 |
Onchocerca volvulus | 0.0043 | 0.0681 | 0.5 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0681 | 0.3031 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Schistosoma mansoni | tyrosine kinase | 0.0032 | 0.0227 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0681 | 0.1094 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0681 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0701 | 0.1143 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0701 | 0.1603 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0681 | 0.1465 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0681 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0681 | 0.1094 |
Brugia malayi | endoprotease bli-4 precursor | 0.0136 | 0.4373 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0681 | 0.1094 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0701 | 0.1603 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0086 | 0.2358 | 0.514 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0044 | 0.0701 | 0.1143 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0681 | 0.1094 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0032 | 0.0232 | 0.053 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0042 | 0.0625 | 0.1283 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0681 | 0.3031 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0681 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0681 | 0.3031 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0083 | 0.2246 | 0.487 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0032 | 0.0232 | 0.1032 |
Brugia malayi | celfurPC protein | 0.011 | 0.3324 | 0.747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.