Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0439 | 0.0439 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.186 | 1 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.186 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0439 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.186 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0076 | 0.0076 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0138 | 0.6709 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0205 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0041 | 0.0041 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0041 | 0.0041 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0041 | 0.1976 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0041 | 0.0041 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.186 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0041 | 0.0925 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0309 | 0.0309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 3 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis BCG | ChEMBL. | 24246731 |
MIC (functional) | = 10.819 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC 960 assay | ChEMBL. | 24836065 |
Potency (functional) | 0.2818 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.