Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0088 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.3618 | 0.3095 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0035 | 0.3618 | 0.5 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.8235 | 0.8219 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.3618 | 0.356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.3852 | 0.3513 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.3618 | 0.3083 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3852 | 0.3797 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.3852 | 0.3513 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0773 | 0.0265 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0088 | 1 | 0.5 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0088 | 1 | 0.5 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0088 | 1 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0773 | 0.0265 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0088 | 1 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0088 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0088 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0432 | 0.0432 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0088 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0522 | 0.0436 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0088 | 1 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.3852 | 0.3797 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0088 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0088 | 1 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0432 | 0.0432 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0088 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0088 | 1 | 0.5 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0088 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0088 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0432 | 0.0432 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0088 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.