TDR Targets

Basic information

Technical information

TDR Targets ID: 1385738
Name: 4-(3-imidazol-1-ylpropylamino)-3-nitrobenzene sulfonamide
MW: 325.344 | Formula: C12H15N5O4S
H donors: 2 H acceptors: 5 LogP: 0.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1cc(ccc1NCCCn1cncc1)S(=O)(=O)N
InChi: 1S/C12H15N5O4S/c13-22(20,21)10-2-3-11(12(8-10)17(18)19)15-4-1-6-16-7-5-14-9-16/h2-3,5,7-9,15H,1,4,6H2,(H2,13,20,21)
InChiKey: VFGFLUVHYXJUBY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(3-imidazol-1-ylpropylamino)-3-nitro-benzenesulfonamide
4-[3-(1-imidazolyl)propylamino]-3-nitrobenzenesulfonamide
ZINC05268339
T5360238

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	allatostatin A receptor	0.0017	0.0304	0.0231
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.2289	0.5849
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0304	0.0451
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	GnHR receptor homolog	0.0017	0.0304	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	7tm_1 domain containing protein	0.0017	0.0304	0.0231
Loa Loa (eye worm)	AUR protein kinase	0.0116	0.2728	0.6222
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0304	0.0451
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0304	0.0304
Echinococcus multilocularis	aurora kinase A	0.0116	0.2728	0.2673
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0304	0.0445
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0304	0.0304
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0304	0.0451
Trichomonas vaginalis	STE family protein kinase	0.0077	0.1786	0.4746
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	amine GPCR	0.0017	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0304	0.0231
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.2289	0.518
Echinococcus multilocularis	dnaJ subfamily B	0.0413	1	1
Schistosoma mansoni	protein kinase	0.0116	0.2728	0.2728
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0017	0.0304	0.0231
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0017	0.0304	0.0445
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2289	0.5344
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0476	0.5
Echinococcus multilocularis	muscleblind protein	0.018	0.4313	0.427
Leishmania major	protein kinase, putative	0.0116	0.2728	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Schistosoma mansoni	hypothetical protein	0.0017	0.0304	0.0304
Echinococcus multilocularis	orexin receptor type 2	0.0017	0.0304	0.0231
Echinococcus granulosus	7TM GPCR rhodopsin	0.0017	0.0304	0.0231
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0017	0.0304	0.0231
Brugia malayi	sulfakinin receptor protein	0.0017	0.0304	0.0451
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.2289	0.5177
Echinococcus multilocularis	G protein coupled receptor 139	0.0017	0.0304	0.0231
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0017	0.0304	0.0231
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0017	0.0304	0.0231
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0017	0.0304	0.0445
Echinococcus granulosus	neuropeptide FF receptor 2	0.0017	0.0304	0.0231
Brugia malayi	putative neuropeptide receptor	0.0017	0.0304	0.0451
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0304	0.0304
Loa Loa (eye worm)	TTK protein kinase	0.0155	0.3698	0.8535
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0304	0.0445
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Echinococcus granulosus	G protein coupled receptor 139	0.0017	0.0304	0.0231
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.1111	0.2891
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	sex peptide receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	G-protein coupled receptor	0.0017	0.0304	0.0451
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0304	0.0231
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0304	0.0451
Echinococcus granulosus	g-protein coupled receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	hypothetical protein	0.0017	0.0304	0.0231
Trypanosoma brucei	aurora B kinase	0.0116	0.2728	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0017	0.0304	0.0231
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	amine GPCR	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Onchocerca volvulus		0.0029	0.0608	0.0894
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0304	0.0304
Loa Loa (eye worm)	AUR protein kinase	0.0116	0.2728	0.6222
Brugia malayi	Dopamine receptor	0.0017	0.0304	0.0451
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0155	0.3698	0.3651
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0304	0.0304
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0017	0.0304	0.0231
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0304	0.0451
Brugia malayi	serine/threonine-protein kinase 6	0.0116	0.2728	0.6224
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0017	0.0304	0.0304
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0155	0.3698	1
Schistosoma mansoni	amine GPCR	0.0017	0.0304	0.0304
Echinococcus granulosus	dual specificity mitogen activated protein	0.0077	0.1786	0.1724
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.0476	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0304	0.0451
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Schistosoma mansoni	opsin-like receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2289	0.2289
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0304	0.0445
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0077	0.1786	0.1724
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.2728	0.7333
Schistosoma mansoni	hypothetical protein	0.0017	0.0304	0.0304
Brugia malayi	G protein-coupled receptor	0.0017	0.0304	0.0451
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.0476	0.5
Brugia malayi	AKH receptor	0.0017	0.0304	0.0451
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0077	0.1786	0.3977
Entamoeba histolytica	protein kinase domain containing protein	0.0116	0.2728	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0304	0.0231
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0017	0.0304	0.0231
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0304	0.0445
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0116	0.2728	0.2673
Onchocerca volvulus		0.0084	0.1952	0.4854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0304	0.0451
Echinococcus granulosus	somatostatin receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0304	0.0304
Echinococcus granulosus	biogenic amine 5HT receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0017	0.0304	0.0304
Brugia malayi	Muscleblind-like protein	0.018	0.4313	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0084	0.1952	0.1891
Schistosoma mansoni	protein kinase	0.0077	0.1786	0.1786
Echinococcus granulosus	neuropeptide s receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus multilocularis	somatostatin receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	amine GPCR	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	amine GPCR	0.0017	0.0304	0.0304
Entamoeba histolytica	protein kinase , putative	0.0116	0.2728	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0077	0.1786	0.3981
Echinococcus multilocularis	serotonin receptor	0.0017	0.0304	0.0231
Brugia malayi	G-protein coupled receptor	0.0017	0.0304	0.0451
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Mycobacterium leprae	conserved hypothetical protein	0.0024	0.0476	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	hypothetical protein	0.0017	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Brugia malayi	neuropeptide F receptor	0.0017	0.0304	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1952	0.4372
Schistosoma mansoni	growth hormone secretagogue receptor	0.0017	0.0304	0.0304
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0017	0.0304	0.0445
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0155	0.3698	0.3698
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus granulosus	aurora kinase A	0.0116	0.2728	0.2673
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0304	0.0231
Loa Loa (eye worm)	melatonin receptor type 1A	0.0017	0.0304	0.0445
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.1111	0.2891
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1242	0.3403
Trichomonas vaginalis	STE family protein kinase	0.0077	0.1786	0.4746
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.2289	0.8053
Giardia lamblia	Kinase, PLK	0.0098	0.2289	0.2632
Echinococcus multilocularis	serotonin receptor	0.0017	0.0304	0.0231
Entamoeba histolytica	protein kinase, putative	0.0116	0.2728	1
Entamoeba histolytica	protein kinase, putative	0.0116	0.2728	1
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0304	0.0304
Toxoplasma gondii	aurora kinase	0.0116	0.2728	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0017	0.0304	0.0304
Echinococcus multilocularis	dro:myosuppressin receptor	0.0017	0.0304	0.0231
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.2289	0.8053
Echinococcus granulosus	muscleblind protein	0.018	0.4313	0.427
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0017	0.0304	0.0231
Trichomonas vaginalis	CAMK family protein kinase	0.0155	0.3698	1
Echinococcus multilocularis	g-protein coupled receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	myosin xvIII	0.0017	0.0304	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.2728	0.7333
Schistosoma mansoni	histamine h1 receptor	0.0017	0.0304	0.0304
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0.0476	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	hypothetical protein	0.0413	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0304	0.0231
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.2728	0.7333
Echinococcus granulosus	dro:myosuppressin receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Brugia malayi	Serotonin receptor	0.0017	0.0304	0.0451
Echinococcus granulosus	sex peptide receptor	0.0017	0.0304	0.0231
Brugia malayi	larval opioid receptor	0.0017	0.0304	0.0451
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0304	0.0231
Trypanosoma cruzi	aurora B kinase, putative	0.0116	0.2728	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	hypothetical protein	0.0017	0.0304	0.0304
Schistosoma mansoni	opsin-like receptor	0.0017	0.0304	0.0304
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0017	0.0304	0.0231
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0304	0.0231
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0304	0.0451
Giardia lamblia	Aurora kinase	0.0116	0.2728	0.4924
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0077	0.1786	0.5818
Echinococcus granulosus	fmrfamide receptor	0.0017	0.0304	0.0231
Schistosoma mansoni	opsin-like receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	cpg binding protein	0.0029	0.0608	0.0608
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0116	0.2728	1
Echinococcus granulosus	allatostatin A receptor	0.0017	0.0304	0.0231
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0116	0.2728	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0077	0.1786	0.5818
Schistosoma mansoni	serine/threonine protein kinase	0.0116	0.2728	0.2728
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Trichomonas vaginalis	CAMK family protein kinase	0.0155	0.3698	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0304	0.0451
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.0476	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Schistosoma mansoni	kinase	0.0051	0.1142	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.018	0.4313	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0304	0.0451
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.2289	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0116	0.2728	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0084	0.1952	0.1952
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0304	0.0231
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.2289	0.2231
Echinococcus granulosus	serotonin receptor	0.0017	0.0304	0.0231
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0304	0.0451
Echinococcus granulosus	L aminoadipate semialdehyde	0.0084	0.1952	0.1891
Echinococcus multilocularis	cpg binding protein	0.0031	0.0648	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Giardia lamblia	Kinase, TTK	0.0155	0.3698	1
Brugia malayi	RE15519p	0.0017	0.0304	0.0451
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0155	0.3698	0.3651
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0017	0.0304	0.0445
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Loa Loa (eye worm)	TYRA-2 protein	0.0017	0.0304	0.0445
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0304	0.0451
Loa Loa (eye worm)	hypothetical protein	0.018	0.4313	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0304	0.0231
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2289	0.6128
Brugia malayi	hypothetical protein	0.0017	0.0304	0.0451
Brugia malayi	serine/threonine protein kinase 6	0.0116	0.2728	0.6224
Trichomonas vaginalis	STE family protein kinase	0.0077	0.1786	0.4746
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Trypanosoma brucei	polo-like protein kinase	0.0098	0.2289	0.8053
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Brugia malayi	Protein kinase domain containing protein	0.0155	0.3698	0.8536
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	adenoreceptor	0.0017	0.0304	0.0304
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0304	0.0231
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0017	0.0304	0.0304
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0608	0.1174
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0017	0.0304	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus multilocularis	muscleblind protein 1	0.018	0.4313	0.427
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0304	0.0231
Brugia malayi	serine/threonine kinase 12	0.0116	0.2728	0.6224
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0084	0.1952	0.4375
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0017	0.0304	0.0304
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0116	0.2728	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	cpg binding protein	0.0031	0.0648	0.0578
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0304	0.0231
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0017	0.0304	0.0304
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2289	0.5344
Echinococcus granulosus	orexin receptor type 2	0.0017	0.0304	0.0231
Echinococcus multilocularis	neuropeptide s receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Echinococcus granulosus	neuropeptide receptor A26	0.0017	0.0304	0.0231
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0017	0.0304	0.0304
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0017	0.0304	0.0231
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0304	0.0231
Brugia malayi	neuropeptide F receptor	0.0017	0.0304	0.0451
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Echinococcus granulosus	biogenic amine 5HT receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	AUR protein kinase	0.0116	0.2728	0.6222
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0304	0.0231
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0304	0.0231
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0017	0.0304	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.2728	0.7333
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	Serotonin receptor	0.0017	0.0304	0.0451
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0304	0.0304
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0017	0.0304	0.0304
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0304	0.0304
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1403	0.1403
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0608	0.1168
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0116	0.2728	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0304	0.0304
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0116	0.2728	0.2673
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0304	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0304	0.0445
Brugia malayi	follicle stimulating hormone receptor	0.0017	0.0304	0.0451
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.0476	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5012 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	11.2202 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1538853

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1385738