Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0822 | 0.1417 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0171 | 0.5802 | 1 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0171 | 0.5802 | 1 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0171 | 0.5802 | 1 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0171 | 0.5802 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0871 | 0.1501 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0106 | 0.3416 | 0.5 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0171 | 0.5802 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8732 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0871 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5802 | 0.6645 |
Plasmodium falciparum | transporter, putative | 0.0171 | 0.5802 | 0.5 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0171 | 0.5802 | 0.6645 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8732 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0871 | 0.1501 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0871 | 0.0997 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0871 | 0.1501 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0871 | 0.1501 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0106 | 0.3416 | 1 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0171 | 0.5802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0871 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5802 | 0.6645 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0871 | 0.1501 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0171 | 0.5802 | 0.5802 |
Plasmodium vivax | metal transporter, putative | 0.0171 | 0.5802 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0871 | 0.1501 |
Onchocerca volvulus | 0.0036 | 0.0871 | 0.0871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.