Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.003 | 0.1613 | 0.0965 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0718 | 0.5 |
Schistosoma mansoni | amyloid beta A4 protein related | 0.0067 | 0.6504 | 0.6233 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0718 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.6161 | 0.6161 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0718 | 0.5 |
Onchocerca volvulus | 0.003 | 0.1613 | 0.5 | |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0094 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.003 | 0.1613 | 0.1345 |
Brugia malayi | Protein kinase domain containing protein | 0.003 | 0.1613 | 0.0965 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0718 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.004 | 0.2942 | 0.2397 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.031 | 0.031 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.003 | 0.1613 | 1 |
Echinococcus granulosus | amyloid beta A4 protein | 0.0067 | 0.6504 | 0.6392 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.002 | 0.031 | 0.031 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0094 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.004 | 0.2942 | 0.2717 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0094 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0718 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0094 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0094 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0718 | 0.4448 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.003 | 0.1613 | 0.1613 |
Echinococcus multilocularis | amyloid beta A4 protein | 0.0067 | 0.6504 | 0.6233 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0094 | 1 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0094 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0094 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0094 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.003 | 0.1613 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0094 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1613 | 1 |
Brugia malayi | abnormal cell lineage protein 10 (Protein lin-10), putative | 0.006 | 0.5579 | 0.5237 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0718 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1613 | 0.1613 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0718 | 0.5 |
Brugia malayi | hypothetical protein | 0.0064 | 0.6161 | 0.5864 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.1613 | 0.0965 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0094 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.003 | 0.1613 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.002 | 0.031 | 0.1919 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0057 | 0.5199 | 1 |
Brugia malayi | Kringle domain containing protein | 0.003 | 0.1613 | 0.0965 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0718 | 0.0421 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0094 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0718 | 0.5 |
Loa Loa (eye worm) | X11 protein | 0.0067 | 0.6504 | 0.6504 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.1613 | 0.1999 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0057 | 0.5199 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0718 | 0.0718 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1689 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.1192 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.