Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha-ps | 0.0042 | 0.0279 | 0.0508 |
Echinococcus granulosus | integrin alpha ps | 0.0081 | 0.143 | 0.1998 |
Schistosoma mansoni | integrin alpha | 0.018 | 0.4385 | 0.7989 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0056 | 0.0696 | 0.0696 |
Echinococcus multilocularis | integrin alpha ps | 0.0039 | 0.018 | 0.0251 |
Echinococcus multilocularis | integrin alpha ps | 0.0081 | 0.143 | 0.1998 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.018 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.308 | 0.308 |
Echinococcus granulosus | integrin alpha ps | 0.0039 | 0.018 | 0.0251 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0256 | 0.0466 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0256 | 0.0256 |
Echinococcus granulosus | integrin alpha 3 | 0.0138 | 0.3135 | 0.4381 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0824 | 0.0824 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0696 | 0.0696 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0136 | 0.308 | 0.308 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Schistosoma mansoni | integrin beta subunit | 0.0217 | 0.5489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0279 | 0.0279 |
Brugia malayi | Kelch motif family protein | 0.0056 | 0.0696 | 0.0696 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0824 | 0.0824 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0696 | 0.0696 |
Echinococcus granulosus | integrin beta 2 | 0.0273 | 0.7156 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.018 | 0.018 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.018 | 0.4385 | 0.4385 |
Echinococcus multilocularis | integrin beta 2 | 0.0273 | 0.7156 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0277 | 0.7286 | 0.7286 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.3234 | 0.3234 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0256 | 0.0256 |
Schistosoma mansoni | integrin alpha-ps | 0.0081 | 0.143 | 0.2605 |
Echinococcus multilocularis | integrin alpha ps | 0.0081 | 0.143 | 0.1998 |
Echinococcus multilocularis | integrin alpha 3 | 0.0138 | 0.3135 | 0.4381 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1984 | 0.1984 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6702 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.