Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 0.117 | 0.1135 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.117 | 0.1236 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9182 | 0.9073 |
Echinococcus granulosus | lamin | 0.0033 | 0.117 | 0.1236 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.117 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0156 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.004 | 0.0342 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.117 | 0.1135 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.117 | 0.1236 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.117 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.117 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.117 | 0.1135 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9182 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.113 | 0.9658 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.117 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9182 | 0.9178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.4467 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.