Detailed information for compound 1393675

Basic information

Technical information
  • TDR Targets ID: 1393675
  • Name: N-(5-methyl-1,2-oxazol-3-yl)-2-(2-pyridin-4-y lethylsulfanyl)acetamide
  • MW: 277.342 | Formula: C13H15N3O2S
  • H donors: 1 H acceptors: 3 LogP: 1.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CSCCc1ccncc1
  • InChi: 1S/C13H15N3O2S/c1-10-8-12(16-18-10)15-13(17)9-19-7-4-11-2-5-14-6-3-11/h2-3,5-6,8H,4,7,9H2,1H3,(H,15,16,17)
  • InChiKey: WURNGZBUUBUMKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-methylisoxazol-3-yl)-2-[2-(4-pyridyl)ethylsulfanyl]acetamide
  • N-(5-methyl-3-isoxazolyl)-2-[2-(4-pyridyl)ethylthio]acetamide
  • N-(5-methylisoxazol-3-yl)-2-[2-(4-pyridyl)ethylthio]acetamide
  • N-(5-methyl-1,2-oxazol-3-yl)-2-(2-pyridin-4-ylethylsulfanyl)ethanamide
  • MLS000120078
  • SMR000096995

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0024 0.0031 1
Leishmania major hypothetical protein, conserved 0.0024 0.0031 0.0195
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0024 0.0031 0.0031
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1586 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0024 0.0031 0.0031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.1586 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0024 0.0031 0.0195
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0024 0.0031 0.0195
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0024 0.0031 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0024 0.0031 0.0195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0024 0.0031 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0024 0.0031 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0031 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0024 0.0031 0.0195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1586 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Leishmania major hypothetical protein, conserved 0.0024 0.0031 0.0195
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0024 0.0031 0.0195
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.1586 0.1586
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0024 0.0031 0.0031
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0024 0.0031 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) PDE1B protein 0.0024 0.0031 0.0031
Plasmodium vivax phosphodiesterase gamma, putative 0.0024 0.0031 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1427 0.1427
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0024 0.0031 0.0195
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0024 0.0031 0.0031
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0024 0.0031 0.0031
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0024 0.0031 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0024 0.0031 0.0195
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0024 0.0031 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.1586 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0024 0.0031 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Giardia lamblia Hypothetical protein 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0293 0.9195 0.9195
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0024 0.0031 0.0195
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0024 0.0031 0.0195
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0024 0.0031 0.0195
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Giardia lamblia hypothetical protein 0.0024 0.0031 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0316 1 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0024 0.0031 0.0195
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0024 0.0031 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0031 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0024 0.0031 0.0195
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0024 0.0031 0.0031
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0024 0.0031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0293 0.9195 0.9195
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0316 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1586 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.1586 0.1586
Plasmodium falciparum phosphodiesterase delta, putative 0.0024 0.0031 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0024 0.0031 0.0195
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0024 0.0031 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.9195 0.9195
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0024 0.0031 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0024 0.0031 1
Loa Loa (eye worm) hypothetical protein 0.0316 1 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0024 0.0031 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0024 0.0031 0.0195
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0024 0.0031 0.0195
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0024 0.0031 0.0195
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1586 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0024 0.0031 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0024 0.0031 0.0031
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0024 0.0031 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0024 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0024 0.0031 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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