Detailed information for compound 1395009

Basic information

Technical information
  • TDR Targets ID: 1395009
  • Name: 7-(1,3-benzodioxol-5-yl)-2-(3-hydroxypropyl)- N-(2-methoxyphenyl)-5-methyl-1,7-dihydro-[1,2 ,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • MW: 463.486 | Formula: C24H25N5O5
  • H donors: 3 H acceptors: 4 LogP: 2.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCc1nn2c(n1)NC(=C(C2c1ccc2c(c1)OCO2)C(=O)Nc1ccccc1OC)C
  • InChi: 1S/C24H25N5O5/c1-14-21(23(31)26-16-6-3-4-7-17(16)32-2)22(15-9-10-18-19(12-15)34-13-33-18)29-24(25-14)27-20(28-29)8-5-11-30/h3-4,6-7,9-10,12,22,30H,5,8,11,13H2,1-2H3,(H,26,31)(H,25,27,28)
  • InChiKey: AMQURPUIZCYQFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Oprea1_777938
  • 7-(1,3-benzodioxol-5-yl)-2-(3-hydroxypropyl)-N-(2-methoxyphenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • MLS000096907
  • AP-906/42126981
  • EU-0047417
  • MLS000911057
  • SMR000074663

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0201 0.0535 0.0535
Plasmodium falciparum phosphodiesterase delta, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0201 0.0535 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0201 0.0535 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0201 0.0535 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0201 0.0535 0.5
Plasmodium falciparum phosphodiesterase gamma, putative 0.0201 0.0535 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.005 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0201 0.0535 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0201 0.0535 0.1406
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0201 0.0535 0.0535
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.005 0.5
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0201 0.0535 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0201 0.0535 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0201 0.0535 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0201 0.0535 0.5
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0201 0.0535 0.0487
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0201 0.0535 0.1406
Loa Loa (eye worm) PDE1B protein 0.0201 0.0535 0.0535
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3499 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0201 0.0535 0.1406
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.005 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0201 0.0535 0.5
Leishmania major hypothetical protein, conserved 0.0201 0.0535 1
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0201 0.0535 0.1406
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0201 0.0535 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0201 0.0535 0.1406
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Giardia lamblia Hypothetical protein 0.0201 0.0535 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.005 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0201 0.0535 0.1406
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Leishmania major hypothetical protein, conserved 0.0201 0.0535 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0201 0.0535 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0201 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0201 0.0535 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0201 0.0535 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0201 0.0535 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.2687 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.0535 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.0201 0.0535 0.0535
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.0201 0.0535 0.0535
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0201 0.0535 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.2486 0.9236 0.9236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0201 0.0535 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0201 0.0535 0.1406
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0201 0.0535 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0201 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Giardia lamblia hypothetical protein 0.0201 0.0535 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0535 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0201 0.0535 0.1406
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0201 0.0535 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0201 0.0535 0.0535
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.2687 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0201 0.0535 0.0535
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.2486 0.9236 0.9236
Loa Loa (eye worm) hypothetical protein 0.0201 0.0535 0.0535
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0201 0.0535 0.0535
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0201 0.0535 0.0487
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0201 0.0535 1
Trypanosoma brucei hypothetical protein, conserved 0.0201 0.0535 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.2687 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0201 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.2486 0.9236 0.9236
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0201 0.0535 0.0487

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.