Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.683 | 0.683 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0167 | 0.6677 | 0.6677 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0113 | 0.356 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.7113 | 0.1312 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.7113 | 0.1312 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.7113 | 0.6525 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6677 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6677 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0167 | 0.6677 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.7113 | 0.6381 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0167 | 0.6677 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0167 | 0.6677 | 0.5835 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0167 | 0.6677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.2022 | 0.0398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.