Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.007 | 0.02 | 0.02 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0187 | 0.1179 | 0.1179 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1419 | 0.552 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0187 | 0.1179 | 0.1179 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0199 | 0.1281 | 0.4753 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0199 | 0.1281 | 0.1281 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0187 | 0.1179 | 0.1179 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Loa Loa (eye worm) | presenilin spe-4 | 0.007 | 0.02 | 0.02 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Brugia malayi | hypothetical protein | 0.007 | 0.02 | 0.02 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.2222 | 0.2222 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0199 | 0.1281 | 0.3338 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.02 | 0.02 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0199 | 0.1281 | 1 |
Echinococcus granulosus | Nicastrin | 0.0097 | 0.0428 | 0.0428 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Echinococcus multilocularis | Nicastrin | 0.0097 | 0.0428 | 0.0428 |
Echinococcus multilocularis | presenilin | 0.0199 | 0.1281 | 0.1281 |
Brugia malayi | Presenilin family protein | 0.0199 | 0.1281 | 0.1281 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.02 | 0.02 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0187 | 0.1179 | 0.1179 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0199 | 0.1281 | 0.4753 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0484 | 0.3663 | 1 |
Echinococcus multilocularis | Nicastrin | 0.0097 | 0.0428 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0428 | 0.0428 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0484 | 0.3663 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0199 | 0.1281 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0428 | 0.0428 |
Brugia malayi | hypothetical protein | 0.007 | 0.02 | 0.02 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.02 | 0.02 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0199 | 0.1281 | 0.4753 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.007 | 0.02 | 0.02 |
Brugia malayi | hypothetical protein | 0.0097 | 0.0428 | 0.0428 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Echinococcus granulosus | presenilin | 0.0199 | 0.1281 | 0.1281 |
Brugia malayi | hypothetical protein | 0.0097 | 0.0428 | 0.0428 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.1327 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.2222 | 0.2222 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.1327 | 0.5007 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1419 | 0.552 |
Toxoplasma gondii | hypothetical protein | 0.007 | 0.02 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0484 | 0.3663 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.2222 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.