Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Saccharomyces cerevisiae | Rce1p | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0111 | 0.2937 | 1 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.2937 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0055 | 0.0583 | 0.1985 |
Schistosoma mansoni | peroxidasin | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Onchocerca volvulus | 0.0055 | 0.0583 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0055 | 0.0583 | 0.1985 |
Schistosoma mansoni | peroxidasin | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1494 | 0.5085 |
Echinococcus multilocularis | peroxidasin | 0.0055 | 0.0583 | 0.1707 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.2937 | 1 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1494 | 0.5085 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | Animal haem peroxidase family protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0111 | 0.2937 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0098 | 0.0335 |
Brugia malayi | Animal haem peroxidase family protein | 0.0055 | 0.0583 | 0.1985 |
Onchocerca volvulus | Peroxidasin homolog | 0.0055 | 0.0583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0805 | 0.2741 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0098 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1494 | 0.5085 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1494 | 0.5085 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0805 | 0.2741 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0098 | 0.0335 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0098 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | Peroxidasin | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0098 | 0.0335 |
Onchocerca volvulus | 0.0055 | 0.0583 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0055 | 0.0583 | 0.1985 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0098 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1494 | 0.5085 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1494 | 0.4915 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0111 | 0.2937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0098 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0111 | 0.2937 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0111 | 0.2937 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | Blistered cuticle protein 3 | 0.0055 | 0.0583 | 0.1985 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.2937 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0098 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0111 | 0.2937 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1494 | 0.5085 |
Onchocerca volvulus | 0.0055 | 0.0583 | 1 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1494 | 0.5085 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0805 | 0.2741 |
Onchocerca volvulus | Peroxidasin homolog | 0.0055 | 0.0583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0098 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2937 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0098 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0055 | 0.0583 | 0.1707 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | Animal haem peroxidase family protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0055 | 0.0583 | 0.1985 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1494 | 0.4915 |
Onchocerca volvulus | Peroxidase homolog | 0.0055 | 0.0583 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0098 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.2937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0098 | 0.0335 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1494 | 0.5085 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0098 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Onchocerca volvulus | Dual oxidase homolog | 0.0055 | 0.0583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0111 | 0.2937 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0805 | 0.2741 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0098 | 0.0335 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1494 | 0.5085 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0098 | 0.0335 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0055 | 0.0583 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1494 | 0.5085 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0111 | 0.2937 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1494 | 0.5085 |
Onchocerca volvulus | Peroxidase homolog | 0.0055 | 0.0583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0583 | 0.1985 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0098 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 18.24 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.