Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Schistosoma japonicum | IPR000276,Rhodopsin-like GPCR superfamily,domain-containing | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0461 | 0.1471 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0461 | 0.1471 | 0.5 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0461 | 0.1471 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.1522 | 0.9982 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.