Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.1729 | 0.1412 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0074 | 0.397 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0074 | 0.397 | 0.3815 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0074 | 0.397 | 0.3738 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0074 | 0.397 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0074 | 0.397 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0074 | 0.397 | 0.3815 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.3936 | 0.9915 |
Onchocerca volvulus | 0.0035 | 0.1729 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2896 | 0.2714 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.037 | 0.0123 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0074 | 0.397 | 0.3738 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0074 | 0.397 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2227 | 0.5561 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0074 | 0.397 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.025 | 0.0526 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1841 | 0.458 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0074 | 0.397 | 0.3743 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2227 | 0.5561 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0074 | 0.397 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0074 | 0.397 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.7266 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0074 | 0.397 | 0.5 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0074 | 0.397 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2896 | 0.2714 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0207 | 0.0521 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.1729 | 0.1419 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2896 | 0.2714 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1841 | 0.458 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1729 | 0.4294 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2227 | 0.2028 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2896 | 0.2623 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2896 | 0.2629 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.1841 | 0.1633 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0074 | 0.397 | 0.3743 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.7266 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0074 | 0.397 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2896 | 0.7266 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0207 | 0.0521 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.037 | 0.0123 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0207 | 0.0521 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2227 | 0.1935 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2227 | 0.2028 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.1841 | 0.1633 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2896 | 0.2714 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0074 | 0.397 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.1735 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 10 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.