Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.3518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0033 | 0.0439 | 0.1145 |
Toxoplasma gondii | hypothetical protein | 0.0258 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0439 | 0.1028 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.2165 | 0.5649 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.4272 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0113 | 0.3833 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.0439 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0439 | 0.0439 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.3518 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0033 | 0.0439 | 0.1145 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2165 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5068 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0113 | 0.3833 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0113 | 0.3833 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3202 | 0.3202 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0439 | 0.1028 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2165 | 0.5068 |
Echinococcus granulosus | voltage gated potassium channel | 0.0033 | 0.0439 | 0.1145 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.2165 | 0.5649 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0113 | 0.3833 | 0.3833 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0258 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.4272 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0033 | 0.0439 | 0.1145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.