Detailed information for compound 1412879

Basic information

Technical information
  • TDR Targets ID: 1412879
  • Name: 3-(1,1-dioxothiolan-3-yl)-5-(pyridin-3-ylmeth ylidene)-2-sulfanylidene-1,3-thiazolidin-4-on e
  • MW: 340.441 | Formula: C13H12N2O3S3
  • H donors: 0 H acceptors: 4 LogP: 1.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1S/C(=C\c2cccnc2)/C(=O)N1C1CCS(=O)(=O)C1
  • InChi: 1S/C13H12N2O3S3/c16-12-11(6-9-2-1-4-14-7-9)20-13(19)15(12)10-3-5-21(17,18)8-10/h1-2,4,6-7,10H,3,5,8H2/b11-6-
  • InChiKey: SPNNEPQLTTUSOV-WDZFZDKYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-3-(1,1-dioxothiolan-3-yl)-5-(pyridin-3-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
  • 3-(1,1-dioxothiolan-3-yl)-5-(3-pyridylmethylene)-2-thioxo-thiazolidin-4-one
  • (5Z)-3-(1,1-dioxothiolan-3-yl)-5-(3-pyridylmethylene)-2-thioxo-thiazolidin-4-one
  • 3-(1,1-dioxo-3-thiolanyl)-5-(3-pyridylmethylene)-2-thioxo-4-thiazolidinone
  • (5Z)-3-(1,1-dioxo-3-thiolanyl)-5-(3-pyridylmethylene)-2-thioxo-4-thiazolidinone
  • 3-(1,1-diketothiolan-3-yl)-5-(3-pyridylmethylene)-2-thioxo-thiazolidin-4-one
  • (5Z)-3-(1,1-diketothiolan-3-yl)-5-(3-pyridylmethylene)-2-thioxo-thiazolidin-4-one
  • SMR000212146
  • STOCK1S-73769
  • 3-(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-5-[1-pyridin-3-yl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one
  • MLS000588330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor 0.0018 0.0001 0.0001
Echinococcus granulosus lamin dm0 0.0033 0.013 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0001 0.0001
Echinococcus granulosus muscleblind protein 0.018 0.1397 0.1996
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.018 0.1397 0.1996
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis musashi 0.0033 0.013 0.0184
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Dopamine receptor protein 1 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.018 0.1397 0.1397
Brugia malayi Dopamine receptor protein 2 0.0018 0.0001 0.0001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0001 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi GnHR receptor homolog 0.0018 0.0001 0.0001
Schistosoma mansoni lamin 0.0033 0.013 0.0184
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0043 0.0223 0.0318
Echinococcus multilocularis muscleblind protein 1 0.018 0.1397 0.1996
Brugia malayi Dopamine receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi RE15519p 0.0018 0.0001 0.0001
Brugia malayi AKH receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi larval opioid receptor 0.0018 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.018 0.1397 0.1397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi G protein-coupled receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0001 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0223 0.0318
Brugia malayi neuropeptide F receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus geminin 0.0205 0.1605 0.2293
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0001 0.0001
Brugia malayi G-protein coupled receptor 0.0018 0.0001 0.0001
Onchocerca volvulus Huntingtin homolog 0.0148 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis lamin 0.0033 0.013 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1184 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0033 0.013 0.1153
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0223 0.0318
Loa Loa (eye worm) hypothetical protein 0.0148 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0033 0.013 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0148 0.1119 0.1119
Brugia malayi intermediate filament protein 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0043 0.0223 0.0223
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6995 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Melatonin receptor type 1A 0.0018 0.0001 0.0001
Onchocerca volvulus 0.0033 0.013 0.1153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0223 0.0318
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0001 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni lamin 0.0033 0.013 0.0184
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.5
Echinococcus multilocularis lamin dm0 0.0033 0.013 0.0184
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1184 1 1
Brugia malayi sulfakinin receptor protein 0.0018 0.0001 0.0001
Echinococcus granulosus lamin 0.0033 0.013 0.0184
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6995 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.013 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi ORL1-like opioid receptor 0.0018 0.0001 0.0001
Brugia malayi G-protein coupled receptor 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0205 0.1605 0.2293
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0018 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.018 0.1397 0.1397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6995 1
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.1184 1 1
Echinococcus multilocularis geminin 0.0205 0.1605 0.2293
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.1605 0.2293
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0001 0.0001
Onchocerca volvulus Huntingtin homolog 0.0148 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1119 0.1119
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 33.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2071, AID2092] ChEMBL. No reference
IC50 (functional) = 49.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2071, AID2092] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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