Detailed information for compound 1414107

Basic information

Technical information
  • TDR Targets ID: 1414107
  • Name: 2-(2-chloro-4-piperidin-1-ylsulfonylphenoxy)- 1-pyrrolidin-1-ylethanone
  • MW: 386.894 | Formula: C17H23ClN2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC1)COc1ccc(cc1Cl)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C17H23ClN2O4S/c18-15-12-14(25(22,23)20-10-2-1-3-11-20)6-7-16(15)24-13-17(21)19-8-4-5-9-19/h6-7,12H,1-5,8-11,13H2
  • InChiKey: PDCFNZWAOQODBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-chloro-4-(1-piperidylsulfonyl)phenoxy]-1-pyrrolidin-1-yl-ethanone
  • 2-[2-chloro-4-(1-piperidylsulfonyl)phenoxy]-1-1-pyrrolidinylethanone
  • 2-(2-chloro-4-piperidinosulfonyl-phenoxy)-1-pyrrolidin-1-yl-ethanone
  • 2-(2-chloro-4-piperidin-1-ylsulfonyl-phenoxy)-1-pyrrolidin-1-yl-ethanone
  • 2-[2-Chloro-4-(piperidine-1-sulfonyl)-phenoxy]-1-pyrrolidin-1-yl-ethanone
  • BAS 12634424
  • ZINC04502420

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni kinase 0.0059 0.0323 0.0728
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0125 0.0125
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0647 0.0647
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0711 0.444 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0028 0.0125 0.0281
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni opsin-like receptor 0.0028 0.0125 0.0281
Schistosoma mansoni neuropeptide receptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) AUR protein kinase 0.013 0.077 0.1713
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0125 0.0254
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0647 0.1209
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0125 0.0125
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0127 0.0753 0.0753
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0125 0.0125
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0113 0.5
Giardia lamblia Kinase, PLK 0.011 0.0647 0.0361
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0711 0.444 0.444
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0125 0.0254
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0647 0.8118
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0647 0.0647
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.28 0.28
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0125 0.0125
Brugia malayi G-protein coupled receptor 0.0028 0.0125 0.0256
Brugia malayi serine/threonine kinase 12 0.013 0.077 0.1714
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0088 0.0505 0.1114
Echinococcus granulosus somatostatin receptor 0.0028 0.0125 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0125 0.0125
Echinococcus granulosus cpg binding protein 0.0034 0.0162 0.0162
Toxoplasma gondii aurora kinase 0.013 0.077 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Plasmodium vivax serine/threonine protein kinase 6, putative 0.013 0.077 1
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0127 0.0753 0.1672
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.053 0.053
Entamoeba histolytica protein kinase , putative 0.013 0.077 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0125 0.0125
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0028 0.0125 0.0281
Echinococcus multilocularis serotonin receptor 0.0028 0.0125 0.0125
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0113 0.5
Schistosoma mansoni neuropeptide receptor 0.0028 0.0125 0.0281
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0125 0.0125
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0125 0.0256
Schistosoma mansoni myosin xvIII 0.0028 0.0125 0.0281
Echinococcus granulosus neuropeptide receptor 0.0028 0.0125 0.0125
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0125 0.0281
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni biogenic amine receptor 0.0028 0.0125 0.0281
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0647 0.1435
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi AKH receptor 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0125 0.0125
Brugia malayi ORL1-like opioid receptor 0.0028 0.0125 0.0256
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0125 0.0125
Trichomonas vaginalis STE family protein kinase 0.0088 0.0505 0.0461
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0125 0.0125
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0125 0.0125
Brugia malayi Protein kinase domain containing protein 0.0711 0.444 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi sulfakinin receptor protein 0.0028 0.0125 0.0256
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0125 0.0125
Leishmania major protein kinase, putative 0.013 0.077 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0125 0.0254
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0125 0.0125
Trichomonas vaginalis AGC family protein kinase 0.013 0.077 0.1106
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0125 0.0125
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0125 0.0254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0125 0.0281
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0125 0.0125
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0125 0.0125
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0125 0.0125
Echinococcus granulosus g protein coupled receptor 0.0028 0.0125 0.0125
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0125 0.0281
Brugia malayi putative neuropeptide receptor 0.0028 0.0125 0.0256
Schistosoma mansoni cpg binding protein 0.0032 0.015 0.0339
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0125 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0113 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0125 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Trichomonas vaginalis STE family protein kinase 0.0088 0.0505 0.0461
Brugia malayi serine/threonine protein kinase 6 0.013 0.077 0.1714
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0125 0.0281
Schistosoma mansoni cpg binding protein 0.0034 0.0162 0.0364
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0125 0.0125
Brugia malayi serine/threonine-protein kinase 6 0.013 0.077 0.1714
Schistosoma mansoni hypothetical protein 0.0451 0.28 0.6307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0125 0.0281
Schistosoma mansoni adenoreceptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0125 0.0254
Echinococcus granulosus sex peptide receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0113 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0647 0.5344
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0028 0.0125 0.0281
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0125 0.0281
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0088 0.0505 0.5957
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.013 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0127 0.0753 0.0753
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0375 0.0844
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0125 0.0125
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0125 0.0281
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0125 0.0125
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0329 0.3289
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0113 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni hypothetical protein 0.0127 0.0753 0.1695
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0125 0.0125
Echinococcus granulosus g protein coupled receptor 0.0028 0.0125 0.0125
Schistosoma mansoni cpg binding protein 0.0034 0.0162 0.0364
Schistosoma mansoni histamine h1 receptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) TTK protein kinase 0.0711 0.444 1
Trichomonas vaginalis AGC family protein kinase 0.013 0.077 0.1106
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0125 0.0125
Plasmodium falciparum serine/threonine protein kinase, putative 0.013 0.077 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0125 0.0281
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0125 0.0125
Echinococcus granulosus dual specificity mitogen activated protein 0.0088 0.0505 0.0505
Echinococcus multilocularis serotonin receptor 0.0028 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0028 0.0125 0.0281
Echinococcus multilocularis sex peptide receptor 0.0028 0.0125 0.0125
Brugia malayi Melatonin receptor type 1A 0.0028 0.0125 0.0256
Brugia malayi Dopamine receptor 0.0028 0.0125 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0125 0.0125
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0125 0.0281
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni protein kinase 0.013 0.077 0.1735
Schistosoma mansoni opsin-like receptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0012 0.0012
Brugia malayi RE15519p 0.0028 0.0125 0.0256
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0125 0.0125
Echinococcus granulosus fmrfamide receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Echinococcus granulosus aurora kinase A 0.013 0.077 0.077
Schistosoma mansoni biogenic amine receptor 0.0028 0.0125 0.0281
Echinococcus multilocularis cpg binding protein 0.0034 0.0162 0.0162
Brugia malayi neuropeptide F receptor 0.0028 0.0125 0.0256
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0125 0.0281
Echinococcus granulosus dnaJ subfamily B 0.0451 0.28 0.28
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0125 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0125 0.0281
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Entamoeba histolytica protein kinase, putative 0.013 0.077 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Schistosoma mansoni apoptosis regulator bax 0.0127 0.0753 0.1695
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0125 0.0254
Schistosoma mansoni neuropeptide receptor 0.0028 0.0125 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis aurora kinase A 0.013 0.077 0.077
Echinococcus granulosus g protein coupled receptor 0.0028 0.0125 0.0125
Brugia malayi larval opioid receptor 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0125 0.0281
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0125 0.0281
Schistosoma mansoni opsin-like receptor 0.0028 0.0125 0.0281
Trypanosoma brucei polo-like protein kinase 0.011 0.0647 0.8118
Schistosoma mansoni hypothetical protein 0.0028 0.0125 0.0281
Entamoeba histolytica protein kinase, putative 0.013 0.077 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi Dopamine receptor protein 1 0.0028 0.0125 0.0256
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0088 0.0505 0.5957
Schistosoma mansoni hypothetical protein 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0125 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0647 0.1457
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0125 0.0256
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0125 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Brugia malayi Dopamine receptor protein 2 0.0028 0.0125 0.0256
Echinococcus granulosus neuropeptide receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni neuropeptide receptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus hypothetical protein 0.0028 0.0125 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Brugia malayi G protein-coupled receptor 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Schistosoma mansoni hypothetical protein 0.0028 0.0125 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1592 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis dual specificity mitogen activated protein 0.0088 0.0505 0.0505
Trichomonas vaginalis AGC family protein kinase 0.013 0.077 0.1106
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0125 0.0125
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0125 0.0254
Schistosoma mansoni hypothetical protein 0.0127 0.0753 0.1695
Entamoeba histolytica protein kinase domain containing protein 0.013 0.077 1
Giardia lamblia Kinase, TTK 0.0711 0.444 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.015 0.0312
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0127 0.0753 0.1674
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0125 0.0254
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0711 0.444 1
Trichomonas vaginalis CAMK family protein kinase 0.0711 0.444 1
Schistosoma mansoni hypothetical protein 0.0127 0.0753 0.1695
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Onchocerca volvulus 0.0032 0.015 0.0059
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0113 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0125 0.0281
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0088 0.0505 0.1112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0125 0.0125
Schistosoma mansoni protein kinase 0.0088 0.0505 0.1137
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0647 0.1433
Trichomonas vaginalis STE family protein kinase 0.0088 0.0505 0.0461
Loa Loa (eye worm) AUR protein kinase 0.013 0.077 0.1713
Trypanosoma brucei aurora B kinase 0.013 0.077 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0125 0.0125
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0647 0.8118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0125 0.0125
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0125 0.0256
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0125 0.0281
Giardia lamblia Aurora kinase 0.013 0.077 0.0675
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0012 0.0012
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0125 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.013 0.077 0.1735
Brugia malayi Serotonin receptor 0.0028 0.0125 0.0256
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis somatostatin receptor 0.0028 0.0125 0.0125
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0711 0.444 1
Trichomonas vaginalis AGC family protein kinase 0.013 0.077 0.1106
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0125 0.0125
Echinococcus granulosus orexin receptor type 2 0.0028 0.0125 0.0125
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0125 0.0256
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0125 0.0125
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0125 0.0281
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0125 0.0125
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0125 0.0254
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0125 0.0125
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0127 0.0753 0.1695
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0125 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0125 0.0256
Echinococcus granulosus serotonin receptor 0.0028 0.0125 0.0125
Schistosoma mansoni amine GPCR 0.0028 0.0125 0.0281
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0125 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0125 0.0281
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0711 0.444 0.444
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Brugia malayi CXXC zinc finger family protein 0.0032 0.015 0.0314
Brugia malayi neuropeptide F receptor 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0092 0.053 0.1169
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Echinococcus granulosus serine:threonine protein kinase 12 B 0.013 0.077 0.077
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Brugia malayi Serotonin receptor 0.0028 0.0125 0.0256
Echinococcus granulosus allatostatin A receptor 0.0028 0.0125 0.0125
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0647 0.5344
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.053 0.117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) AUR protein kinase 0.013 0.077 0.1713
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0125 0.0281
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0125 0.0256
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0113 0.5
Onchocerca volvulus 0.0092 0.053 0.0938
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.013 0.077 1
Brugia malayi GnHR receptor homolog 0.0028 0.0125 0.0256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0125 0.0281
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0125 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0647 0.0806
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0125 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0125 0.0281
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0125 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0125 0.0125
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.013 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.013 0.077 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0125 0.0125
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.053 0.053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0125 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0125 0.0125
Loa Loa (eye worm) apoptosis regulator protein 0.0127 0.0753 0.1672
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0125 0.0125
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0125 0.0125
Trypanosoma cruzi aurora B kinase, putative 0.013 0.077 1
Schistosoma mansoni biogenic amine receptor 0.0028 0.0125 0.0281
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.053 0.1193
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi G-protein coupled receptor 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254
Brugia malayi hypothetical protein 0.0028 0.0125 0.0256
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0254

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.