Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0025 | 0.0381 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3312 | 0.284 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3312 | 0.3295 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2731 | 0.4093 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3312 | 0.4973 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.6635 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0025 | 0.0381 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0025 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2731 | 0.4093 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0024 | 0.0659 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0062 | 0.2731 | 0.7808 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0025 | 0.5 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0659 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0659 | 0.0636 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.2731 | 0.2217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3312 | 0.3295 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 0.0659 | 0.0959 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3312 | 0.4973 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2731 | 0.4093 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0659 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.0659 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3312 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0659 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0659 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3312 | 0.4973 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 0.0659 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 0.0659 | 0.0959 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 0.0659 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0197 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.2731 | 0.7808 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.2731 | 0.2712 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.2731 | 0.7808 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3312 | 0.284 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3312 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3312 | 0.3295 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0197 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0135 | 0.6635 | 0.6398 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0659 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.0659 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.2731 | 0.7808 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3312 | 0.4973 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 0.0659 | 0.0636 |
Echinococcus multilocularis | GPCR, family 2 | 0.0062 | 0.2731 | 0.7808 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.6635 | 0.6627 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3312 | 0.4973 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0659 | 0.0636 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.2731 | 0.2217 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3312 | 0.284 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 0.0659 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.2731 | 0.7808 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0025 | 0.00000000053469 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 0.0659 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.2731 | 0.2712 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2731 | 0.4093 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.