Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Isocitrate lyase | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 367 aa | 295 aa | 87.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1432 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1432 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1882 | 1 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0032 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0225 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0032 | 0.159 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0202 | 0.8966 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0032 | 0.159 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0202 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0202 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0225 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0032 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0032 | 0.159 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0202 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0032 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0032 | 0.159 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0032 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0032 | 0.159 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0032 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1882 | 1 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0032 | 0.1426 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1882 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0032 | 0.1426 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.1426 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0136 | 0.6727 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0202 | 0.8966 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0202 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1882 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0032 | 0.159 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0202 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1597 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0032 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0225 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0032 | 0.159 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0032 | 0.159 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0136 | 0.6031 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0032 | 0.159 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0032 | 0.159 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0202 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0032 | 0.1432 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0136 | 0.6031 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0032 | 0.1426 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1882 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0225 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0032 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0032 | 0.1597 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human HL60 cells after 18 hrs by annexin-V labeling-based flow cytometry | ChEMBL. | 22985027 |
IC50 (binding) | > 1000 uM | In vitro inhibition of farnesyl-protein transferase | ChEMBL. | 11755366 |
IC50 (binding) | > 1000 uM | In vitro inhibition of geranylgeranyl-protein transferase type-I | ChEMBL. | 11755366 |
IC50 (binding) | > 1000 uM | In vitro inhibition of farnesyl-protein transferase | ChEMBL. | 11755366 |
IC50 (binding) | > 1000 uM | In vitro inhibition of geranylgeranyl-protein transferase type-I | ChEMBL. | 11755366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 5624 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-12 | References: | 10572116 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 5625 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-12 | References: | 10572116 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 6243 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-12 | References: | 10572116 |
2 literature references were collected for this gene.