Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.4581 | 0.5 | |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7876 | 0.9593 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.7876 | 0.7876 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.821 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.7079 | 0.7079 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.7079 | 0.7079 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.821 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7876 | 0.9593 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.7079 | 0.8622 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0355 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.