Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | telomerase reverse transcriptase | 0.0454 | 0.2713 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0022 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0195 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0022 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0454 | 0.2713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0039 | 0.0754 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0184 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0195 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0039 | 0.0754 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0184 | 0.0201 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0454 | 0.2713 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0454 | 0.2713 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0454 | 0.2713 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0454 | 0.2713 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0418 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0027 | 0.0531 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0195 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0022 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0184 | 0.4331 |
Giardia lamblia | Telomerase catalytic subunit | 0.0454 | 0.2713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0022 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0454 | 0.2713 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0195 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1209 | 0.7262 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0022 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.