Detailed information for compound 1433473

Basic information

Technical information
  • TDR Targets ID: 1433473
  • Name: N-ethyl-[1,3]thiazolo[5,4-b]pyridin-2-amine
  • MW: 179.242 | Formula: C8H9N3S
  • H donors: 1 H acceptors: 2 LogP: 2.33 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc2c(s1)nccc2
  • InChi: 1S/C8H9N3S/c1-2-9-8-11-6-4-3-5-10-7(6)12-8/h3-5H,2H2,1H3,(H,9,11)
  • InChiKey: RWSFBSWRFBRXDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethylthiazolo[5,4-b]pyridin-2-amine
  • N-ethyl-2-thiazolo[5,4-b]pyridinamine
  • ethyl-thiazolo[5,4-b]pyridin-2-yl-amine
  • Oprea1_127622
  • ZINC00128806
  • Maybridge3_007451
  • MLS000860970
  • N-ethyl[1,3]thiazolo[5,4-b]pyridin-2-amine
  • SMR000459754
  • IDI1_018838

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0148 0.0323 0.2611
Onchocerca volvulus 0.03 0.1236 0.268
Loa Loa (eye worm) hypothetical protein 0.0148 0.0323 0.0003
Loa Loa (eye worm) peptidase family M1 containing protein 0.0709 0.3698 0.994
Onchocerca volvulus 0.0148 0.0323 0.07
Echinococcus granulosus puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Echinococcus granulosus puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Brugia malayi hypothetical protein 0.0148 0.0323 0.07
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.03 0.1236 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.03 0.1236 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.1756 1 1
Brugia malayi TATA binding protein associated factor 0.0148 0.0323 0.07
Echinococcus granulosus aminopeptidase N 0.0861 0.461 1
Brugia malayi Peptidase family M1 containing protein 0.0148 0.0323 0.07
Brugia malayi hypothetical protein 0.03 0.1236 0.268
Brugia malayi Peptidase family M1 containing protein 0.03 0.1236 0.268
Onchocerca volvulus Matrix metalloproteinase homolog 0.0148 0.0322 0.0697
Brugia malayi Matrixin family protein 0.0161 0.0402 0.0872
Brugia malayi Peptidase family M1 containing protein 0.0861 0.461 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.03 0.1236 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0148 0.0323 0.0003
Loa Loa (eye worm) matrixin family protein 0.0161 0.0402 0.0237
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0152 0.0343 0.0223
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0152 0.0343 0.2776
Mycobacterium ulcerans aminopeptidase N PepN 0.03 0.1236 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0152 0.0343 0.0047
Loa Loa (eye worm) hypothetical protein 0.0712 0.3718 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0243 0.0891 0.1327
Loa Loa (eye worm) hypothetical protein 0.0148 0.0323 0.0003
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.03 0.1236 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0148 0.0323 0.0003
Loa Loa (eye worm) hypothetical protein 0.0148 0.0323 0.0003
Onchocerca volvulus 0.0861 0.461 1
Trypanosoma brucei Aminopeptidase M1, putative 0.03 0.1236 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.03 0.1236 1
Trypanosoma brucei Aminopeptidase M1, putative 0.03 0.1236 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.03 0.1236 0.2129
Toxoplasma gondii aminopeptidase N, putative 0.1756 1 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.03 0.1236 1
Toxoplasma gondii aminopeptidase n, putative 0.1756 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0561 0.2805 0.7312
Loa Loa (eye worm) aminopeptidase N 0.03 0.1236 0.2691
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0148 0.0323 0.2611
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Toxoplasma gondii aminopeptidase N protein 0.1756 1 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.03 0.1236 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.03 0.1236 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0243 0.0891 0.1327
Echinococcus multilocularis aminopeptidase N 0.0861 0.461 1
Entamoeba histolytica aminopeptidase, putative 0.03 0.1236 0.5
Loa Loa (eye worm) hypothetical protein 0.0152 0.0343 0.0063
Onchocerca volvulus Matrilysin homolog 0.0148 0.0322 0.0697
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Schistosoma mansoni aminopeptidase A (M01 family) 0.0148 0.0323 0.2611
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.03 0.1236 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0343 0.0063
Echinococcus granulosus puromycin sensitive aminopeptidase 0.03 0.1236 0.2129
Trypanosoma cruzi aminopeptidase, putative 0.03 0.1236 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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